tetano
Editor, Senior Moderator
J Clin Lab Anal
. 2022 Mar 9;e24291.
doi: 10.1002/jcla.24291. Online ahead of print.
In-hospital mortality in SARS-CoV-2 stratified by gamma-glutamyl transferase levels
Moudhi Alroomi[SUP] 1 [/SUP], Rajesh Rajan[SUP] 2 [/SUP], Ahmad Alsaber[SUP] 3 [/SUP], Jiazhu Pan[SUP] 3 [/SUP], Mohammed Abdullah[SUP] 1 [/SUP], Hassan Abdelnaby[SUP] 4 5 [/SUP], Wael Aboelhassan[SUP] 6 [/SUP], Noor AlNasrallah[SUP] 7 [/SUP], Bader Al-Bader[SUP] 8 [/SUP], Haya Malhas[SUP] 9 [/SUP], Maryam Ramadhan[SUP] 10 [/SUP], Soumoud Hussein[SUP] 11 [/SUP], Naser Alotaibi[SUP] 7 [/SUP], Mohammad Al Saleh[SUP] 8 [/SUP], Kobalava D Zhanna[SUP] 12 [/SUP], Farah Almutairi[SUP] 8 [/SUP]
Affiliations
Abstract
Background: This study investigates in-hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its relation to serum levels of gamma-glutamyl transferase (GGT).
Methods: Patients were stratified according to serum levels of gamma-glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L).
Results: A total of 802 participants were considered, amongst whom 486 had GGT<50 IU/L and a mean age of 48.1 (16.5) years, whilst 316 had GGT≥50 IU/L and a mean age of 53.8 (14.7) years. The chief sources of SARS-CoV-2 transmission were contact (366, 45.7%) and community (320, 40%). Most patients with GGT≥50 IU/L had either pneumonia (247, 78.2%) or acute respiratory distress syndrome (ARDS) (85, 26.9%), whilst those with GGT<50 IU/L had hypertension (141, 29%) or diabetes mellitus (DM) (147, 30.2%). Mortality was higher amongst patients with GGT≥50 IU/L (54, 17.1%) than amongst those with GGT<50 IU/L (29, 5.9%). More patients with GGT≥50 required high (83, 27.6%) or low (104, 34.6%) levels of oxygen, whereas most of those with GGT<50 had no requirement of oxygen (306, 71.2%). Multivariable logistic regression analysis indicated that GGT≥50 IU/L (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.20-3.45, p=0.009), age (OR: 1.05, 95% CI: 1.03-1.07, p<0.001), hypertension (OR: 2.06, 95% CI: 1.19-3.63, p=0.011), methylprednisolone (OR: 2.96, 95% CI: 1.74-5.01, p<0.001) and fever (OR: 2.03, 95% CI: 1.15-3.68, p=0.016) were significant predictors of all-cause cumulative mortality. A Cox proportional hazards regression model (B = -0.68, SE =0.24, HR =0.51, p = 0.004) showed that patients with GGT<50 IU/L had a 0.51-times lower risk of all-cause cumulative mortality than patients with GGT≥50 IU/L.
Conclusion: Higher levels of serum GGT were found to be an independent predictor of in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; gamma-glutamyl transferase; in-hospital mortality.
. 2022 Mar 9;e24291.
doi: 10.1002/jcla.24291. Online ahead of print.
In-hospital mortality in SARS-CoV-2 stratified by gamma-glutamyl transferase levels
Moudhi Alroomi[SUP] 1 [/SUP], Rajesh Rajan[SUP] 2 [/SUP], Ahmad Alsaber[SUP] 3 [/SUP], Jiazhu Pan[SUP] 3 [/SUP], Mohammed Abdullah[SUP] 1 [/SUP], Hassan Abdelnaby[SUP] 4 5 [/SUP], Wael Aboelhassan[SUP] 6 [/SUP], Noor AlNasrallah[SUP] 7 [/SUP], Bader Al-Bader[SUP] 8 [/SUP], Haya Malhas[SUP] 9 [/SUP], Maryam Ramadhan[SUP] 10 [/SUP], Soumoud Hussein[SUP] 11 [/SUP], Naser Alotaibi[SUP] 7 [/SUP], Mohammad Al Saleh[SUP] 8 [/SUP], Kobalava D Zhanna[SUP] 12 [/SUP], Farah Almutairi[SUP] 8 [/SUP]
Affiliations
- PMID: 35261080
- DOI: 10.1002/jcla.24291
Abstract
Background: This study investigates in-hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its relation to serum levels of gamma-glutamyl transferase (GGT).
Methods: Patients were stratified according to serum levels of gamma-glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L).
Results: A total of 802 participants were considered, amongst whom 486 had GGT<50 IU/L and a mean age of 48.1 (16.5) years, whilst 316 had GGT≥50 IU/L and a mean age of 53.8 (14.7) years. The chief sources of SARS-CoV-2 transmission were contact (366, 45.7%) and community (320, 40%). Most patients with GGT≥50 IU/L had either pneumonia (247, 78.2%) or acute respiratory distress syndrome (ARDS) (85, 26.9%), whilst those with GGT<50 IU/L had hypertension (141, 29%) or diabetes mellitus (DM) (147, 30.2%). Mortality was higher amongst patients with GGT≥50 IU/L (54, 17.1%) than amongst those with GGT<50 IU/L (29, 5.9%). More patients with GGT≥50 required high (83, 27.6%) or low (104, 34.6%) levels of oxygen, whereas most of those with GGT<50 had no requirement of oxygen (306, 71.2%). Multivariable logistic regression analysis indicated that GGT≥50 IU/L (odds ratio [OR]: 2.02, 95% confidence interval [CI]: 1.20-3.45, p=0.009), age (OR: 1.05, 95% CI: 1.03-1.07, p<0.001), hypertension (OR: 2.06, 95% CI: 1.19-3.63, p=0.011), methylprednisolone (OR: 2.96, 95% CI: 1.74-5.01, p<0.001) and fever (OR: 2.03, 95% CI: 1.15-3.68, p=0.016) were significant predictors of all-cause cumulative mortality. A Cox proportional hazards regression model (B = -0.68, SE =0.24, HR =0.51, p = 0.004) showed that patients with GGT<50 IU/L had a 0.51-times lower risk of all-cause cumulative mortality than patients with GGT≥50 IU/L.
Conclusion: Higher levels of serum GGT were found to be an independent predictor of in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; gamma-glutamyl transferase; in-hospital mortality.