tetano
Editor, Senior Moderator
J Clin Med
. 2021 Mar 3;10(5):1039.
doi: 10.3390/jcm10051039.
Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain
Raquel Bened?-Ubieto[SUP] 1 2 [/SUP], Olga Est?vez-V?zquez[SUP] 1 2 [/SUP], Vicente Flores-Perojo[SUP] 3 [/SUP], Ricardo U Mac?as-Rodr?guez[SUP] 4 [/SUP], Astrid Ruiz-Marg?in[SUP] 4 [/SUP], Eduardo Mart?nez-Naves[SUP] 1 5 [/SUP], Jos? R Regueiro[SUP] 1 5 [/SUP], Mat?as A ?vila[SUP] 6 7 8 [/SUP], Christian Trautwein[SUP] 9 [/SUP], Rafael Ba?ares[SUP] 8 10 [/SUP], Jaume Bosch[SUP] 8 11 12 [/SUP], Francisco Javier Cubero[SUP] 1 5 [/SUP], Yulia A Nevzorova[SUP] 1 5 9 [/SUP]
Affiliations
Abstract
The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
Keywords: AST/ALT ratio; SARS-CoV-2; ferritin; liver injury; pandemic.
. 2021 Mar 3;10(5):1039.
doi: 10.3390/jcm10051039.
Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain
Raquel Bened?-Ubieto[SUP] 1 2 [/SUP], Olga Est?vez-V?zquez[SUP] 1 2 [/SUP], Vicente Flores-Perojo[SUP] 3 [/SUP], Ricardo U Mac?as-Rodr?guez[SUP] 4 [/SUP], Astrid Ruiz-Marg?in[SUP] 4 [/SUP], Eduardo Mart?nez-Naves[SUP] 1 5 [/SUP], Jos? R Regueiro[SUP] 1 5 [/SUP], Mat?as A ?vila[SUP] 6 7 8 [/SUP], Christian Trautwein[SUP] 9 [/SUP], Rafael Ba?ares[SUP] 8 10 [/SUP], Jaume Bosch[SUP] 8 11 12 [/SUP], Francisco Javier Cubero[SUP] 1 5 [/SUP], Yulia A Nevzorova[SUP] 1 5 9 [/SUP]
Affiliations
- PMID: 33802486
- DOI: 10.3390/jcm10051039
Abstract
The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
Keywords: AST/ALT ratio; SARS-CoV-2; ferritin; liver injury; pandemic.