tetano
Editor, Senior Moderator
J Clin Med
. 2021 May 10;10(9):2042.
doi: 10.3390/jcm10092042.
Impact of Kidney Failure on the Severity of COVID-19
Dorota Zarębska-Michaluk[SUP] 1 [/SUP], Jerzy Jaroszewicz[SUP] 2 [/SUP], Magdalena Rogalska[SUP] 3 [/SUP], Beata Lorenc[SUP] 4 [/SUP], Marta Rorat[SUP] 5 6 [/SUP], Anna Szymanek-Pasternak[SUP] 5 [/SUP], Anna Piekarska[SUP] 7 [/SUP], Aleksandra Berkan-Kawińska[SUP] 7 [/SUP], Katarzyna Sikorska[SUP] 8 [/SUP], Magdalena Tudrujek-Zdunek[SUP] 9 [/SUP], Barbara Oczko-Grzesik[SUP] 2 [/SUP], Beata Bolewska[SUP] 10 [/SUP], Piotr Czupryna[SUP] 11 [/SUP], Dorota Kozielewicz[SUP] 12 [/SUP], Justyna Kowalska[SUP] 13 [/SUP], Regina Podlasin[SUP] 14 [/SUP], Krzysztof Kłos[SUP] 15 [/SUP], Włodzimierz Mazur[SUP] 16 [/SUP], Piotr Leszczyński[SUP] 17 18 [/SUP], Bartosz Szetela[SUP] 19 [/SUP], Katarzyna Reczko[SUP] 1 [/SUP], Robert Flisiak[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population.
Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online.
Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO[SUB]2[/SUB], the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis.
Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.
Keywords: COVID-19; SARS-CoV-2; kidney failure; mortality.
. 2021 May 10;10(9):2042.
doi: 10.3390/jcm10092042.
Impact of Kidney Failure on the Severity of COVID-19
Dorota Zarębska-Michaluk[SUP] 1 [/SUP], Jerzy Jaroszewicz[SUP] 2 [/SUP], Magdalena Rogalska[SUP] 3 [/SUP], Beata Lorenc[SUP] 4 [/SUP], Marta Rorat[SUP] 5 6 [/SUP], Anna Szymanek-Pasternak[SUP] 5 [/SUP], Anna Piekarska[SUP] 7 [/SUP], Aleksandra Berkan-Kawińska[SUP] 7 [/SUP], Katarzyna Sikorska[SUP] 8 [/SUP], Magdalena Tudrujek-Zdunek[SUP] 9 [/SUP], Barbara Oczko-Grzesik[SUP] 2 [/SUP], Beata Bolewska[SUP] 10 [/SUP], Piotr Czupryna[SUP] 11 [/SUP], Dorota Kozielewicz[SUP] 12 [/SUP], Justyna Kowalska[SUP] 13 [/SUP], Regina Podlasin[SUP] 14 [/SUP], Krzysztof Kłos[SUP] 15 [/SUP], Włodzimierz Mazur[SUP] 16 [/SUP], Piotr Leszczyński[SUP] 17 18 [/SUP], Bartosz Szetela[SUP] 19 [/SUP], Katarzyna Reczko[SUP] 1 [/SUP], Robert Flisiak[SUP] 3 [/SUP]
Affiliations
- PMID: 34068725
- DOI: 10.3390/jcm10092042
Abstract
Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population.
Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online.
Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO[SUB]2[/SUB], the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis.
Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.
Keywords: COVID-19; SARS-CoV-2; kidney failure; mortality.