tetano
Editor, Senior Moderator
J Clin Med
. 2021 Jun 18;10(12):2696.
doi: 10.3390/jcm10122696.
Isolation of Viable SARS-CoV-2 Virus from Feces of an Immunocompromised Patient Suggesting a Possible Fecal Mode of Transmission
Julie Dergham[SUP] 1 2 [/SUP], Jeremy Delerce[SUP] 1 2 [/SUP], Marielle Bedotto[SUP] 1 2 [/SUP], Bernard La Scola[SUP] 1 2 [/SUP], Valérie Moal[SUP] 2 3 [/SUP]
Affiliations
Abstract
(1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease (COVID-19) epidemic cluster associated with a ruptured sewage pipe, we search for such a viable SARS-CoV-2 particle in stool by inoculating 106 samples from 46 patients. (3) Results: We successfully obtained two isolates from a unique patient with kidney transplantation under immunosuppressive therapy who was admitted for severe diarrhea. (4) Conclusions: This report emphasizes that SARS-CoV-2 is an enteric virus, and infectious virus particles can be isolated from the stool of immune-compromised patients like, in our case, kidney transplant recipient. Immune-compromised patients are likely to have massive multiplication of the virus in the gastrointestinal tract and this report suggests possible fecal transmission of SARS-CoV-2.
Keywords: Covid-19; SARS-CoV-2; cell culture; organ transplantation; stools.
. 2021 Jun 18;10(12):2696.
doi: 10.3390/jcm10122696.
Isolation of Viable SARS-CoV-2 Virus from Feces of an Immunocompromised Patient Suggesting a Possible Fecal Mode of Transmission
Julie Dergham[SUP] 1 2 [/SUP], Jeremy Delerce[SUP] 1 2 [/SUP], Marielle Bedotto[SUP] 1 2 [/SUP], Bernard La Scola[SUP] 1 2 [/SUP], Valérie Moal[SUP] 2 3 [/SUP]
Affiliations
- PMID: 34207314
- DOI: 10.3390/jcm10122696
Abstract
(1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease (COVID-19) epidemic cluster associated with a ruptured sewage pipe, we search for such a viable SARS-CoV-2 particle in stool by inoculating 106 samples from 46 patients. (3) Results: We successfully obtained two isolates from a unique patient with kidney transplantation under immunosuppressive therapy who was admitted for severe diarrhea. (4) Conclusions: This report emphasizes that SARS-CoV-2 is an enteric virus, and infectious virus particles can be isolated from the stool of immune-compromised patients like, in our case, kidney transplant recipient. Immune-compromised patients are likely to have massive multiplication of the virus in the gastrointestinal tract and this report suggests possible fecal transmission of SARS-CoV-2.
Keywords: Covid-19; SARS-CoV-2; cell culture; organ transplantation; stools.