tetano
Editor, Senior Moderator
J Clin Med
. 2022 Aug 21;11(16):4903.
doi: 10.3390/jcm11164903.
Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study
Paul Simon[SUP] 1 2 [/SUP], Pierrick Le Borgne[SUP] 1 3 [/SUP], François Lefevbre[SUP] 4 [/SUP], Lauriane Cipolat[SUP] 5 [/SUP], Aline Remillon[SUP] 5 [/SUP], Camille Dib[SUP] 5 [/SUP], Mathieu Hoffmann[SUP] 5 [/SUP], Idalie Gardeur[SUP] 5 [/SUP], Jonathan Sabah[SUP] 6 [/SUP], Sabrina Kepka[SUP] 1 [/SUP], Pascal Bilbault[SUP] 1 2 3 [/SUP], Charles-Eric Lavoignet[SUP] 7 [/SUP], Laure Abensur Vuillaume[SUP] 5 [/SUP], CREMS Network (Clinical Research in Emergency Medicine and Sepsis)
Affiliations
Abstract
(1) Introduction: In the present study, we investigate the prognostic value of platelet-to-lymphocyte ratio (PLR) as a marker of severity and mortality in COVID-19 infection. (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate to severe coronavirus 19 (COVID-19), all of whom were hospitalized after being admitted to the emergency department (ED). (3) Results: A total of 1035 patients were included in our study. Neither lymphocytes, platelets or PLR were associated with disease severity. Lymphocyte count was significantly lower and PLR values were significantly higher in the group of patients who died, and both were associated with mortality in the univariate analysis (OR: 0.524, 95% CI: (0.336-0.815), p = 0.004) and (OR: 1.001, 95% CI: (1.000-1.001), p = 0.042), respectively. However, the only biological parameter significantly associated with mortality in the multivariate analysis was platelet count (OR: 0.996, 95% CI: (0.996-1.000), p = 0.027). The best PLR value for predicting mortality in COVID-19 was 356.6 (OR: 3.793, 95% CI: (1.946-7.394), p < 0.001). (4) Conclusion: A high PLR value is however associated with excess mortality.
Keywords: COVID-19; PLR; mortality; platelet-to-lymphocyte ratio; severity.
. 2022 Aug 21;11(16):4903.
doi: 10.3390/jcm11164903.
Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study
Paul Simon[SUP] 1 2 [/SUP], Pierrick Le Borgne[SUP] 1 3 [/SUP], François Lefevbre[SUP] 4 [/SUP], Lauriane Cipolat[SUP] 5 [/SUP], Aline Remillon[SUP] 5 [/SUP], Camille Dib[SUP] 5 [/SUP], Mathieu Hoffmann[SUP] 5 [/SUP], Idalie Gardeur[SUP] 5 [/SUP], Jonathan Sabah[SUP] 6 [/SUP], Sabrina Kepka[SUP] 1 [/SUP], Pascal Bilbault[SUP] 1 2 3 [/SUP], Charles-Eric Lavoignet[SUP] 7 [/SUP], Laure Abensur Vuillaume[SUP] 5 [/SUP], CREMS Network (Clinical Research in Emergency Medicine and Sepsis)
Affiliations
- PMID: 36013142
- DOI: 10.3390/jcm11164903
Abstract
(1) Introduction: In the present study, we investigate the prognostic value of platelet-to-lymphocyte ratio (PLR) as a marker of severity and mortality in COVID-19 infection. (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate to severe coronavirus 19 (COVID-19), all of whom were hospitalized after being admitted to the emergency department (ED). (3) Results: A total of 1035 patients were included in our study. Neither lymphocytes, platelets or PLR were associated with disease severity. Lymphocyte count was significantly lower and PLR values were significantly higher in the group of patients who died, and both were associated with mortality in the univariate analysis (OR: 0.524, 95% CI: (0.336-0.815), p = 0.004) and (OR: 1.001, 95% CI: (1.000-1.001), p = 0.042), respectively. However, the only biological parameter significantly associated with mortality in the multivariate analysis was platelet count (OR: 0.996, 95% CI: (0.996-1.000), p = 0.027). The best PLR value for predicting mortality in COVID-19 was 356.6 (OR: 3.793, 95% CI: (1.946-7.394), p < 0.001). (4) Conclusion: A high PLR value is however associated with excess mortality.
Keywords: COVID-19; PLR; mortality; platelet-to-lymphocyte ratio; severity.