tetano
Editor, Senior Moderator
J Clin Med
. 2022 Jan 29;11(3):729.
doi: 10.3390/jcm11030729.
Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19
Giulia Renda[SUP] 1 2 [/SUP], Fabrizio Ricci[SUP] 1 3 [/SUP], Enrico Guido Spinoni[SUP] 4 5 [/SUP], Leonardo Grisafi[SUP] 4 5 [/SUP], Damiano D'Ardes[SUP] 2 6 [/SUP], Marco Mennuni[SUP] 4 [/SUP], Claudio Tana[SUP] 2 [/SUP], Andrea Rognoni[SUP] 4 [/SUP], Mattia Bellan[SUP] 4 5 [/SUP], Pier Paolo Sainaghi[SUP] 4 5 [/SUP], Mario Pirisi[SUP] 4 5 [/SUP], Simona De Vecchi[SUP] 4 [/SUP], Sabina Gallina[SUP] 1 [/SUP], Sante Donato Pierdomenico[SUP] 2 7 [/SUP], Francesco Cipollone[SUP] 2 6 [/SUP], Giuseppe Patti[SUP] 4 5 [/SUP]
Affiliations
Abstract
Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during the first wave of the pandemic and followed up to 6 months was included. The primary endpoint was all-cause mortality. The co-primary endpoint was the incidence of the composite outcome of major adverse cardiac and cerebrovascular events (MACCE: cardiovascular death, myocardial infarction, stroke, pulmonary embolism, acute heart failure, or hospitalization for cardiovascular causes). The mean follow-up duration was 6 ± 2 months. The incidence of all-cause death was 4.7%. At multivariate analysis, age was the only independent predictor of mortality (aHR 1.08, 95% CI 1.01-1.16). MACCE occurred in 7.2% of patients. After adjustment, female sex (aHR 2.6, 95% CI 1.05-6.52), in-hospital acute heart failure during index hospitalization (aHR 3.45, 95% CI 1.19-10), and prevalent atrial fibrillation (aHR 3.05, 95% CI 1.13-8.24) significantly predicted the incident risk of MACCE. These findings may help to identify patients for whom a closer and more accurate surveillance after discharge for COVID-19 should be considered.
Keywords: COVID-19; cardiovascular events; follow-up; mortality.
. 2022 Jan 29;11(3):729.
doi: 10.3390/jcm11030729.
Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19
Giulia Renda[SUP] 1 2 [/SUP], Fabrizio Ricci[SUP] 1 3 [/SUP], Enrico Guido Spinoni[SUP] 4 5 [/SUP], Leonardo Grisafi[SUP] 4 5 [/SUP], Damiano D'Ardes[SUP] 2 6 [/SUP], Marco Mennuni[SUP] 4 [/SUP], Claudio Tana[SUP] 2 [/SUP], Andrea Rognoni[SUP] 4 [/SUP], Mattia Bellan[SUP] 4 5 [/SUP], Pier Paolo Sainaghi[SUP] 4 5 [/SUP], Mario Pirisi[SUP] 4 5 [/SUP], Simona De Vecchi[SUP] 4 [/SUP], Sabina Gallina[SUP] 1 [/SUP], Sante Donato Pierdomenico[SUP] 2 7 [/SUP], Francesco Cipollone[SUP] 2 6 [/SUP], Giuseppe Patti[SUP] 4 5 [/SUP]
Affiliations
- PMID: 35160182
- DOI: 10.3390/jcm11030729
Abstract
Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during the first wave of the pandemic and followed up to 6 months was included. The primary endpoint was all-cause mortality. The co-primary endpoint was the incidence of the composite outcome of major adverse cardiac and cerebrovascular events (MACCE: cardiovascular death, myocardial infarction, stroke, pulmonary embolism, acute heart failure, or hospitalization for cardiovascular causes). The mean follow-up duration was 6 ± 2 months. The incidence of all-cause death was 4.7%. At multivariate analysis, age was the only independent predictor of mortality (aHR 1.08, 95% CI 1.01-1.16). MACCE occurred in 7.2% of patients. After adjustment, female sex (aHR 2.6, 95% CI 1.05-6.52), in-hospital acute heart failure during index hospitalization (aHR 3.45, 95% CI 1.19-10), and prevalent atrial fibrillation (aHR 3.05, 95% CI 1.13-8.24) significantly predicted the incident risk of MACCE. These findings may help to identify patients for whom a closer and more accurate surveillance after discharge for COVID-19 should be considered.
Keywords: COVID-19; cardiovascular events; follow-up; mortality.