tetano
Editor, Senior Moderator
J Clin Med
. 2021 Sep 6;10(17):4018.
doi: 10.3390/jcm10174018.
Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019
Alessandra Oliva[SUP] 1 [/SUP], Emanuele Rando[SUP] 1 2 [/SUP], Dania Al Ismail[SUP] 1 [/SUP], Massimiliano De Angelis[SUP] 1 [/SUP], Francesca Cancelli[SUP] 1 [/SUP], Maria Claudia Miele[SUP] 1 [/SUP], Raissa Aronica[SUP] 1 [/SUP], Vera Mauro[SUP] 1 [/SUP], Federica Di Timoteo[SUP] 1 [/SUP], Lorenzo Loffredo[SUP] 3 [/SUP], Claudio M Mastroianni[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: E-selectin is a recognized marker of endothelial activation; however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-admitted and non-admitted, survived and non-survived patients and those with or without thrombosis.
Methods: A single-center study of patients with COVID-19 hospitalized at Policlinico Umberto I (Rome) from March to May 2020 was performed. Simple and multiple logistic regression models were developed.
Results: One hundred patients were included, with a median age (IQR) of 65 years (58-78). Twenty-nine (29%) were admitted to ICU, twenty-eight (28%) died and nineteen (19%) had a thrombotic event. The median value (IQR) of sE-selectin was 26.1 ng/mL (18.1-35). sE-selectin values did not differ between deceased and survivors (p = 0.06) and among patients with or without a thrombotic event (p = 0.22). Compared with patients who did not receive ICU treatments, patients requiring ICU care had higher levels of sE-selectin (36.6 vs. 24.1 ng/mL; p < 0.001). In the multiple logistic regression model, sE-selectin levels > 33 ng/mL, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] < 200 and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] 200-300 were significantly associated with an increased risk of ICU admission. sE-selectin values significantly correlated with a neutrophil count (R = 0.32 (p = 0.001)) and the number of days from the symptoms onset to hospitalization (R = 0.28 (p = 0.004)).
Conclusions: sE-selectin levels are predictive of ICU admission in COVID-19 patients. Since data on the relation between sE-selectin and COVID-19 are scarce, this study aims to contribute toward the comprehension of the pathogenic aspects of COVID-19 disease, giving a possible clinical marker able to predict its severity.
Keywords: COVID-19; E-selectin; SARS-CoV-2; endothelial activation.
. 2021 Sep 6;10(17):4018.
doi: 10.3390/jcm10174018.
Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019
Alessandra Oliva[SUP] 1 [/SUP], Emanuele Rando[SUP] 1 2 [/SUP], Dania Al Ismail[SUP] 1 [/SUP], Massimiliano De Angelis[SUP] 1 [/SUP], Francesca Cancelli[SUP] 1 [/SUP], Maria Claudia Miele[SUP] 1 [/SUP], Raissa Aronica[SUP] 1 [/SUP], Vera Mauro[SUP] 1 [/SUP], Federica Di Timoteo[SUP] 1 [/SUP], Lorenzo Loffredo[SUP] 3 [/SUP], Claudio M Mastroianni[SUP] 1 [/SUP]
Affiliations
- PMID: 34501466
- DOI: 10.3390/jcm10174018
Abstract
Introduction: E-selectin is a recognized marker of endothelial activation; however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-admitted and non-admitted, survived and non-survived patients and those with or without thrombosis.
Methods: A single-center study of patients with COVID-19 hospitalized at Policlinico Umberto I (Rome) from March to May 2020 was performed. Simple and multiple logistic regression models were developed.
Results: One hundred patients were included, with a median age (IQR) of 65 years (58-78). Twenty-nine (29%) were admitted to ICU, twenty-eight (28%) died and nineteen (19%) had a thrombotic event. The median value (IQR) of sE-selectin was 26.1 ng/mL (18.1-35). sE-selectin values did not differ between deceased and survivors (p = 0.06) and among patients with or without a thrombotic event (p = 0.22). Compared with patients who did not receive ICU treatments, patients requiring ICU care had higher levels of sE-selectin (36.6 vs. 24.1 ng/mL; p < 0.001). In the multiple logistic regression model, sE-selectin levels > 33 ng/mL, PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] < 200 and PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] 200-300 were significantly associated with an increased risk of ICU admission. sE-selectin values significantly correlated with a neutrophil count (R = 0.32 (p = 0.001)) and the number of days from the symptoms onset to hospitalization (R = 0.28 (p = 0.004)).
Conclusions: sE-selectin levels are predictive of ICU admission in COVID-19 patients. Since data on the relation between sE-selectin and COVID-19 are scarce, this study aims to contribute toward the comprehension of the pathogenic aspects of COVID-19 disease, giving a possible clinical marker able to predict its severity.
Keywords: COVID-19; E-selectin; SARS-CoV-2; endothelial activation.