tetano
Editor, Senior Moderator
J Clin Med
. 2020 Oct 28;9(11):E3484.
doi: 10.3390/jcm9113484.
Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
Elena de Dios[SUP] 1 2 [/SUP], Cesar Rios-Navarro[SUP] 3 [/SUP], Nerea Perez-Sole[SUP] 3 [/SUP], Jose Gavara[SUP] 3 [/SUP], Victor Marcos-Garces[SUP] 4 [/SUP], Enrique Rodr?guez[SUP] 3 5 [/SUP], Arturo Carratal?[SUP] 3 5 [/SUP], Maria J Forner[SUP] 2 3 6 [/SUP], Jorge Navarro[SUP] 3 7 [/SUP], Maria L Blasco[SUP] 3 8 [/SUP], Elvira Bondia[SUP] 9 [/SUP], Jaime Signes-Costa[SUP] 3 9 [/SUP], Jose M Vila[SUP] 3 10 [/SUP], Maria J Forteza[SUP] 11 [/SUP], Francisco J Chorro[SUP] 1 2 3 4 [/SUP], Vicente Bodi[SUP] 1 2 3 4 [/SUP]
Affiliations
Abstract
This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.
Keywords: COVID-19; lymphocyte; myocardial infarction; neutrophils; prognosis; severity.
. 2020 Oct 28;9(11):E3484.
doi: 10.3390/jcm9113484.
Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19
Elena de Dios[SUP] 1 2 [/SUP], Cesar Rios-Navarro[SUP] 3 [/SUP], Nerea Perez-Sole[SUP] 3 [/SUP], Jose Gavara[SUP] 3 [/SUP], Victor Marcos-Garces[SUP] 4 [/SUP], Enrique Rodr?guez[SUP] 3 5 [/SUP], Arturo Carratal?[SUP] 3 5 [/SUP], Maria J Forner[SUP] 2 3 6 [/SUP], Jorge Navarro[SUP] 3 7 [/SUP], Maria L Blasco[SUP] 3 8 [/SUP], Elvira Bondia[SUP] 9 [/SUP], Jaime Signes-Costa[SUP] 3 9 [/SUP], Jose M Vila[SUP] 3 10 [/SUP], Maria J Forteza[SUP] 11 [/SUP], Francisco J Chorro[SUP] 1 2 3 4 [/SUP], Vicente Bodi[SUP] 1 2 3 4 [/SUP]
Affiliations
- PMID: 33126723
- DOI: 10.3390/jcm9113484
Abstract
This study aimed to assess the time course of circulating neutrophil and lymphocyte counts and their ratio (NLR) in ST-segment elevation myocardial infarction (STEMI) and coronavirus disease (COVID)-19 and explore their associations with clinical events and structural damage. Circulating neutrophil, lymphocyte and NLR were sequentially measured in 659 patients admitted for STEMI and in 103 COVID-19 patients. The dynamics detected in STEMI (within a few hours) were replicated in COVID-19 (within a few days). In both entities patients with events and with severe structural damage displayed higher neutrophil and lower lymphocyte counts. In both scenarios, higher maximum neutrophil and lower minimum lymphocyte counts were associated with more events and more severe organ damage. NLR was higher in STEMI and COVID-19 patients with the worst clinical and structural outcomes. A canonical deregulation of the immune response occurs in STEMI and COVID-19 patients. Boosted circulating innate (neutrophilia) and depressed circulating adaptive immunity (lymphopenia) is associated with more events and severe organ damage. A greater understanding of these critical illnesses is pivotal to explore novel alternative therapies.
Keywords: COVID-19; lymphocyte; myocardial infarction; neutrophils; prognosis; severity.