tetano
Editor, Senior Moderator
J Clin Med
. 2025 Mar 12;14(6):1909.
doi: 10.3390/jcm14061909. The Prevalence of Previous Coronavirus Disease-19 in Patients with Pulmonary Thromboembolism and Its Effect on Embolism Severity
Nagihan Durmuş Koçak[SUP] 1 [/SUP], Nuri Tutar[SUP] 2 [/SUP], Gizem Çil[SUP] 3 [/SUP], Emine Afşin[SUP] 4 [/SUP], Ayşegül Şentürk[SUP] 5 [/SUP], Derya Aydın[SUP] 6 [/SUP], Buket Mermit[SUP] 7 [/SUP], Elif Torun Parmaksız[SUP] 1 [/SUP], Mustafa Çolak[SUP] 8 [/SUP], Elif Yıldırım[SUP] 9 [/SUP], Songül Özyurt[SUP] 10 [/SUP], Gülru Polat[SUP] 11 [/SUP], Elif Tanrıverdi[SUP] 12 [/SUP], İlknur Kaya[SUP] 13 [/SUP], Nur Aleyna Yetkin[SUP] 2 [/SUP], Elif Yılmazel Uçar[SUP] 3 [/SUP], Sibel Doğru[SUP] 14 [/SUP], Talat Kilic[SUP] 15 [/SUP], Hatice Arzu Uçar[SUP] 16 [/SUP], Serdar Berk[SUP] 17 [/SUP], Tuğba Çiçek[SUP] 18 [/SUP], Emine Ozsari[SUP] 4 [/SUP], Gamze Kırkıl[SUP] 19 [/SUP], Halil İbrahim Yakar[SUP] 20 [/SUP], Ersin Alkılınç[SUP] 21 [/SUP], Ali Tabaru[SUP] 22 [/SUP], Esra Yarar[SUP] 23 [/SUP], Emine Aksoy[SUP] 9 [/SUP], Burcu Akkök[SUP] 24 [/SUP], Şebnem Emine Parspur[SUP] 13 [/SUP], Ercan Kurtipek[SUP] 25 [/SUP], Fatih Uzer[SUP] 26 [/SUP], Utku Tapan[SUP] 27 [/SUP], Dildar Duman[SUP] 9 [/SUP], Dursun Tatar[SUP] 11 [/SUP], Gülistan Karadeniz[SUP] 11 [/SUP], İclal Hocanlı[SUP] 28 [/SUP], Özge Oral Tapan[SUP] 27 [/SUP], Kadir Canoğlu[SUP] 29 [/SUP], Fulsen Bozkuş[SUP] 24 [/SUP], Nevra Gullu Arslan[SUP] 30 [/SUP], Ömer Tamer Doğan[SUP] 17 [/SUP], Mahşuk Taylan[SUP] 14 [/SUP], Ayşe Pala[SUP] 31 [/SUP]
Affiliations
Background/Objectives: The association between past coronavirus disease-19 (COVID-19) infection and pulmonary thromboembolism (PTE) is a potential research topic. We aimed to research the prevalence of previous COVID-19 infection in patients with PTE and to determine whether there is a difference in embolism severity in these cases. Methods: Study design: Multicenter, observational, cross-sectional. Patients diagnosed with PTE between 11 March 2022 and 11 March 2023 were prospectively included in this study, excluding cases with PTE along with active COVID-19, patients under the age of 18, and pregnant patients. Group 1 consisted of PTE cases with previous COVID-19, and Group 2 consisted of PTE cases without previous COVID-19. Key variables are D-Dimer level, right ventricle/left ventricle (RV/LV) ratio, simplified pulmonary embolism severity score, and treatment type. Results: A total of 1185 patients (Group 1; n = 360, Group 2; n = 825) were included in this study. The proportion of patients with RV/LV ratio > 1 on computed tomography pulmonary angiography (CTPA) was significantly high in Group 2 compared to Group 1 (27.9% vs. 19.7%, p = 0.003). In multivariate logistic regression analysis, the absence of any identifiable risk factor for PTE was found to be a 0.46-fold protective factor in the presence of previous COVID-19 (OR: 0.456 95% CI: 0.274-0.760, Wald = 9.070, df = 1, p = 0.003) and an RV/LV ratio > 1 on CTPA was found to be a 0.60-fold protective factor (OR: 0.603, 95% CI: 0.365-0.998, Wald = 3.874, df = 1, p = 0.049). Conclusions: The prevalence of previous COVID-19 infection in PTE cases was 30.4%, and 26.3% of idiopathic cases had previous COVID-19 infection. Although the parameters related to embolism severity were higher in the non-COVID-19 group, multivariate analyses revealed a 2.2-fold increased risk for idiopathic PTE and a 1.7-fold increased risk for RV/LV ratio > 1 on CTPA in patients without COVID-19 compared to those with prior COVID-19.
Keywords: COVID-19; hospital mortality; patient acuity; pulmonary embolism; risk factors.
. 2025 Mar 12;14(6):1909.
doi: 10.3390/jcm14061909. The Prevalence of Previous Coronavirus Disease-19 in Patients with Pulmonary Thromboembolism and Its Effect on Embolism Severity
Nagihan Durmuş Koçak[SUP] 1 [/SUP], Nuri Tutar[SUP] 2 [/SUP], Gizem Çil[SUP] 3 [/SUP], Emine Afşin[SUP] 4 [/SUP], Ayşegül Şentürk[SUP] 5 [/SUP], Derya Aydın[SUP] 6 [/SUP], Buket Mermit[SUP] 7 [/SUP], Elif Torun Parmaksız[SUP] 1 [/SUP], Mustafa Çolak[SUP] 8 [/SUP], Elif Yıldırım[SUP] 9 [/SUP], Songül Özyurt[SUP] 10 [/SUP], Gülru Polat[SUP] 11 [/SUP], Elif Tanrıverdi[SUP] 12 [/SUP], İlknur Kaya[SUP] 13 [/SUP], Nur Aleyna Yetkin[SUP] 2 [/SUP], Elif Yılmazel Uçar[SUP] 3 [/SUP], Sibel Doğru[SUP] 14 [/SUP], Talat Kilic[SUP] 15 [/SUP], Hatice Arzu Uçar[SUP] 16 [/SUP], Serdar Berk[SUP] 17 [/SUP], Tuğba Çiçek[SUP] 18 [/SUP], Emine Ozsari[SUP] 4 [/SUP], Gamze Kırkıl[SUP] 19 [/SUP], Halil İbrahim Yakar[SUP] 20 [/SUP], Ersin Alkılınç[SUP] 21 [/SUP], Ali Tabaru[SUP] 22 [/SUP], Esra Yarar[SUP] 23 [/SUP], Emine Aksoy[SUP] 9 [/SUP], Burcu Akkök[SUP] 24 [/SUP], Şebnem Emine Parspur[SUP] 13 [/SUP], Ercan Kurtipek[SUP] 25 [/SUP], Fatih Uzer[SUP] 26 [/SUP], Utku Tapan[SUP] 27 [/SUP], Dildar Duman[SUP] 9 [/SUP], Dursun Tatar[SUP] 11 [/SUP], Gülistan Karadeniz[SUP] 11 [/SUP], İclal Hocanlı[SUP] 28 [/SUP], Özge Oral Tapan[SUP] 27 [/SUP], Kadir Canoğlu[SUP] 29 [/SUP], Fulsen Bozkuş[SUP] 24 [/SUP], Nevra Gullu Arslan[SUP] 30 [/SUP], Ömer Tamer Doğan[SUP] 17 [/SUP], Mahşuk Taylan[SUP] 14 [/SUP], Ayşe Pala[SUP] 31 [/SUP]
Affiliations
- PMID: 40142721
- DOI: 10.3390/jcm14061909
Background/Objectives: The association between past coronavirus disease-19 (COVID-19) infection and pulmonary thromboembolism (PTE) is a potential research topic. We aimed to research the prevalence of previous COVID-19 infection in patients with PTE and to determine whether there is a difference in embolism severity in these cases. Methods: Study design: Multicenter, observational, cross-sectional. Patients diagnosed with PTE between 11 March 2022 and 11 March 2023 were prospectively included in this study, excluding cases with PTE along with active COVID-19, patients under the age of 18, and pregnant patients. Group 1 consisted of PTE cases with previous COVID-19, and Group 2 consisted of PTE cases without previous COVID-19. Key variables are D-Dimer level, right ventricle/left ventricle (RV/LV) ratio, simplified pulmonary embolism severity score, and treatment type. Results: A total of 1185 patients (Group 1; n = 360, Group 2; n = 825) were included in this study. The proportion of patients with RV/LV ratio > 1 on computed tomography pulmonary angiography (CTPA) was significantly high in Group 2 compared to Group 1 (27.9% vs. 19.7%, p = 0.003). In multivariate logistic regression analysis, the absence of any identifiable risk factor for PTE was found to be a 0.46-fold protective factor in the presence of previous COVID-19 (OR: 0.456 95% CI: 0.274-0.760, Wald = 9.070, df = 1, p = 0.003) and an RV/LV ratio > 1 on CTPA was found to be a 0.60-fold protective factor (OR: 0.603, 95% CI: 0.365-0.998, Wald = 3.874, df = 1, p = 0.049). Conclusions: The prevalence of previous COVID-19 infection in PTE cases was 30.4%, and 26.3% of idiopathic cases had previous COVID-19 infection. Although the parameters related to embolism severity were higher in the non-COVID-19 group, multivariate analyses revealed a 2.2-fold increased risk for idiopathic PTE and a 1.7-fold increased risk for RV/LV ratio > 1 on CTPA in patients without COVID-19 compared to those with prior COVID-19.
Keywords: COVID-19; hospital mortality; patient acuity; pulmonary embolism; risk factors.