tetano
Editor, Senior Moderator
J Clin Neurosci
. 2021 Oct 29;S0967-5868(21)00530-0.
doi: 10.1016/j.jocn.2021.10.023. Online ahead of print.
Descriptive analysis of Acute Ischemic stroke in COVID-19 patients through the course of the COVID-19 pandemic
Jay Liuhong Liu[SUP] 1 [/SUP], Keval Shah[SUP] 1 [/SUP], Amin Marji[SUP] 1 [/SUP], Ricky Sareini[SUP] 2 [/SUP], Amman Bhasin[SUP] 2 [/SUP], Shishir Rao[SUP] 1 [/SUP], Wazim Mohamed[SUP] 1 [/SUP], Kumar Rajamani[SUP] 1 [/SUP], Parthasarathi Chamiraju[SUP] 3 [/SUP], Ayaz Khawaja[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) has been associated with Acute Ischemic Stroke (AIS). Here, we characterize our institutional experience with management of COVID-19 and AIS. Baseline demographics, clinical, imaging, and outcomes data were determined in patients with COVID-19 and AIS presenting within March 2020 to October 2020, and November 2020 to August 2021, based on institutional COVID-19 hospitalization volume. Of 2512 COVID-19 patients, 35 (1.39%, mean age 63.3 years, 54% women) had AIS. AIS recognition was frequently delayed after COVID-19 symptoms (median 19.5 days). Four patients (11%) were on therapeutic anticoagulation at AIS recognition. AIS mechanism was undetermined or due to multiple etiologies in most cases (n = 20, 57%). Three patients underwent IV TPA, and three underwent mechanical thrombectomy, of which two suffered re-occlusion. Three patients had incomplete mRNA vaccination course. Fourteen (40%) died, with 26 (74%) having poor outcomes. Critical COVID-19 severity was associated with worsened mortality (p = 0.02). More patients (12/16; 75%) had either worsened or similar 3-month functional outcomes, than those with improvement, indicating the devastating impact of co-existing AIS and COVID-19. Comparative analysis showed that patients in the later cohort had earlier AIS presentation, fewer stroke risk factors, more comprehensive workup, more defined stroke mechanisms, less instance of critical COVID-19 severity, more utilization of IV TPA, and a trend towards worse outcomes for the sub-group of mild-to-moderate COVID-19 severity. AIS incidence, NIHSS, and overall outcomes were similar. Further studies should investigate outcomes beyond 3 months and their predictive factors, impact of completed vaccination course, and access to neurologic care.
Keywords: Acute ischemic stroke; COVID-19; Encephalopathy; Large vessel occlusion; SARS-CoV-2.
. 2021 Oct 29;S0967-5868(21)00530-0.
doi: 10.1016/j.jocn.2021.10.023. Online ahead of print.
Descriptive analysis of Acute Ischemic stroke in COVID-19 patients through the course of the COVID-19 pandemic
Jay Liuhong Liu[SUP] 1 [/SUP], Keval Shah[SUP] 1 [/SUP], Amin Marji[SUP] 1 [/SUP], Ricky Sareini[SUP] 2 [/SUP], Amman Bhasin[SUP] 2 [/SUP], Shishir Rao[SUP] 1 [/SUP], Wazim Mohamed[SUP] 1 [/SUP], Kumar Rajamani[SUP] 1 [/SUP], Parthasarathi Chamiraju[SUP] 3 [/SUP], Ayaz Khawaja[SUP] 4 [/SUP]
Affiliations
- PMID: 34801399
- DOI: 10.1016/j.jocn.2021.10.023
Abstract
Coronavirus disease 2019 (COVID-19) has been associated with Acute Ischemic Stroke (AIS). Here, we characterize our institutional experience with management of COVID-19 and AIS. Baseline demographics, clinical, imaging, and outcomes data were determined in patients with COVID-19 and AIS presenting within March 2020 to October 2020, and November 2020 to August 2021, based on institutional COVID-19 hospitalization volume. Of 2512 COVID-19 patients, 35 (1.39%, mean age 63.3 years, 54% women) had AIS. AIS recognition was frequently delayed after COVID-19 symptoms (median 19.5 days). Four patients (11%) were on therapeutic anticoagulation at AIS recognition. AIS mechanism was undetermined or due to multiple etiologies in most cases (n = 20, 57%). Three patients underwent IV TPA, and three underwent mechanical thrombectomy, of which two suffered re-occlusion. Three patients had incomplete mRNA vaccination course. Fourteen (40%) died, with 26 (74%) having poor outcomes. Critical COVID-19 severity was associated with worsened mortality (p = 0.02). More patients (12/16; 75%) had either worsened or similar 3-month functional outcomes, than those with improvement, indicating the devastating impact of co-existing AIS and COVID-19. Comparative analysis showed that patients in the later cohort had earlier AIS presentation, fewer stroke risk factors, more comprehensive workup, more defined stroke mechanisms, less instance of critical COVID-19 severity, more utilization of IV TPA, and a trend towards worse outcomes for the sub-group of mild-to-moderate COVID-19 severity. AIS incidence, NIHSS, and overall outcomes were similar. Further studies should investigate outcomes beyond 3 months and their predictive factors, impact of completed vaccination course, and access to neurologic care.
Keywords: Acute ischemic stroke; COVID-19; Encephalopathy; Large vessel occlusion; SARS-CoV-2.