tetano
Editor, Senior Moderator
J Clin Virol Plus
. 2022 Feb;2(1):100062.
doi: 10.1016/j.jcvp.2022.100062. Epub 2022 Jan 10.
Case series of HIV SARS-CoV-2 co-infection in Chinese adults
Rita Wai-Yin Ng[SUP] 1 [/SUP], Chun-Kwok Wong[SUP] 2 [/SUP], Grace Chung-Yan Lui[SUP] 3 [/SUP], Eugene Yuk-Keung Tso[SUP] 4 [/SUP], Zigui Chen[SUP] 1 [/SUP], Owen Tak-Yin Tsang[SUP] 5 [/SUP], Siaw Shi Boon[SUP] 1 [/SUP], Christopher Koon-Chi Lai[SUP] 1 [/SUP], Kitty Sau-Chun Fung[SUP] 6 [/SUP], Apple Chung-Man Yeung[SUP] 1 [/SUP], Wendy Ching-Sze Ho[SUP] 1 [/SUP], David Shu-Cheong Hui[SUP] 3 7 [/SUP], Paul Kay-Sheung Chan[SUP] 1 8 [/SUP], Jacky Man-Chun Chan[SUP] 5 [/SUP]
Affiliations
Abstract
Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong.
Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed.
Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset.
Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
Keywords: Adults; COVID-19; Coinfection; Human immunodeficiency virus; Severe respiratory syndrome coronavirus 2.
. 2022 Feb;2(1):100062.
doi: 10.1016/j.jcvp.2022.100062. Epub 2022 Jan 10.
Case series of HIV SARS-CoV-2 co-infection in Chinese adults
Rita Wai-Yin Ng[SUP] 1 [/SUP], Chun-Kwok Wong[SUP] 2 [/SUP], Grace Chung-Yan Lui[SUP] 3 [/SUP], Eugene Yuk-Keung Tso[SUP] 4 [/SUP], Zigui Chen[SUP] 1 [/SUP], Owen Tak-Yin Tsang[SUP] 5 [/SUP], Siaw Shi Boon[SUP] 1 [/SUP], Christopher Koon-Chi Lai[SUP] 1 [/SUP], Kitty Sau-Chun Fung[SUP] 6 [/SUP], Apple Chung-Man Yeung[SUP] 1 [/SUP], Wendy Ching-Sze Ho[SUP] 1 [/SUP], David Shu-Cheong Hui[SUP] 3 7 [/SUP], Paul Kay-Sheung Chan[SUP] 1 8 [/SUP], Jacky Man-Chun Chan[SUP] 5 [/SUP]
Affiliations
- PMID: 35262035
- PMCID: PMC8743445
- DOI: 10.1016/j.jcvp.2022.100062
Abstract
Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong.
Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed.
Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset.
Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
Keywords: Adults; COVID-19; Coinfection; Human immunodeficiency virus; Severe respiratory syndrome coronavirus 2.