tetano
Editor, Senior Moderator
J Contemp Dent Pract
. 2020 Dec 1;21(12):1305-1306.
Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research
Gargi S Sarode[SUP] 1 [/SUP], Sachin C Sarode[SUP] 2 [/SUP], Amol R Gadbail[SUP] 3 [/SUP], Shailesh Gondivkar[SUP] 4 [/SUP], Nilesh K Sharma[SUP] 5 [/SUP], Shankargouda Patil[SUP] 6 [/SUP]
Affiliations
Abstract
It is well known that angiotensin-converting enzyme 2 (ACE2) is an important host factor responsible for the attachment of severe acute respiratory syndrome coronavirus clad 2 (SARS-CoV-2). ACE2 has been predominantly reported to be present in lungs and nasal mucosa, which is the most common site for the initiation of COVID-19.[SUP]1[/SUP] Apart from lungs, ACE2 is also expressed in heart, blood vessels, kidneys, brain, intestines, etc.[SUP]2[/SUP] Recently various locations of the oral cavity have been found to be associated with differential expression of ACE2 protein, with the tongue being the most common site.[SUP]3[/SUP] Moreover, the salivary glands have also been regarded as a potential source of SARS-CoV-2 infection due to the presence of the ACE2 receptor.[SUP]4[/SUP] However, till date there is no strong scientific evidence that has proved the existence and interaction of ACE2 protein and spike receptor of SARS-CoV-2 on oral mucosal and salivary gland epithelial cells.
. 2020 Dec 1;21(12):1305-1306.
Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research
Gargi S Sarode[SUP] 1 [/SUP], Sachin C Sarode[SUP] 2 [/SUP], Amol R Gadbail[SUP] 3 [/SUP], Shailesh Gondivkar[SUP] 4 [/SUP], Nilesh K Sharma[SUP] 5 [/SUP], Shankargouda Patil[SUP] 6 [/SUP]
Affiliations
- PMID: 33893249
Abstract
It is well known that angiotensin-converting enzyme 2 (ACE2) is an important host factor responsible for the attachment of severe acute respiratory syndrome coronavirus clad 2 (SARS-CoV-2). ACE2 has been predominantly reported to be present in lungs and nasal mucosa, which is the most common site for the initiation of COVID-19.[SUP]1[/SUP] Apart from lungs, ACE2 is also expressed in heart, blood vessels, kidneys, brain, intestines, etc.[SUP]2[/SUP] Recently various locations of the oral cavity have been found to be associated with differential expression of ACE2 protein, with the tongue being the most common site.[SUP]3[/SUP] Moreover, the salivary glands have also been regarded as a potential source of SARS-CoV-2 infection due to the presence of the ACE2 receptor.[SUP]4[/SUP] However, till date there is no strong scientific evidence that has proved the existence and interaction of ACE2 protein and spike receptor of SARS-CoV-2 on oral mucosal and salivary gland epithelial cells.