tetano
Editor, Senior Moderator
J Cutan Pathol
. 2022 Feb 11.
doi: 10.1111/cup.14213. Online ahead of print.
A Rare Case of Papular-Purpuric "Gloves and Socks" Syndrome Associated with Influenza
Brandon Zelman[SUP] 1 [/SUP], Aaron Muhlbauer[SUP] 2 [/SUP], Wendy Kim[SUP] 3 [/SUP], Jodi Speiser[SUP] 1 [/SUP]
Affiliations
Abstract
Papular-purpuric "gloves and socks" syndrome (PPGSS) is a unique, self-limited dermatosis characterized by edema, erythema, and pruritic petechiae and papules in a distinct "gloves and socks" distribution. This is often accompanied by systemic symptoms, including fever, lymphadenopathy, asthenia, myalgia, and arthralgias. PPGSS has also been described as a manifestation of an underlying immunological mechanism that can be triggered by viral or drug-related antigens. A 32-year-old male developed a painful eruption on the bilateral hands and feet after being diagnosed with influenza B. On examination, scattered papular purpura with occasional overlying scale were noted on the bilateral hands, fingers, feet, toes, volar wrists, and ankles. Histopathologic sections showed a mixed pattern of inflammation with interface and spongiotic changes. A parakeratotic scale with overlying basket-weave orthokeratosis was also seen. Within the epidermis, there was intra-epidermal vesicles and Langerhans cell microabscess formation with scattered apoptotic keratinocytes. The underlying dermis showed a superficial perivascular lymphocytic infiltrate with mild edematous changes, and extravasation of red blood cells. Clinicopathologic correlation strongly supported a diagnosis of popular-purpuric gloves and socks syndrome. The influenza virus has never been reported in association with PPGSS; thus, this case outlines an important new variant that clinicians should be familiar with. This article is protected by copyright. All rights reserved.
Keywords: PPGSS; Papular-purpuric “gloves and socks” syndrome; gloves and socks syndrome.
. 2022 Feb 11.
doi: 10.1111/cup.14213. Online ahead of print.
A Rare Case of Papular-Purpuric "Gloves and Socks" Syndrome Associated with Influenza
Brandon Zelman[SUP] 1 [/SUP], Aaron Muhlbauer[SUP] 2 [/SUP], Wendy Kim[SUP] 3 [/SUP], Jodi Speiser[SUP] 1 [/SUP]
Affiliations
- PMID: 35148432
- DOI: 10.1111/cup.14213
Abstract
Papular-purpuric "gloves and socks" syndrome (PPGSS) is a unique, self-limited dermatosis characterized by edema, erythema, and pruritic petechiae and papules in a distinct "gloves and socks" distribution. This is often accompanied by systemic symptoms, including fever, lymphadenopathy, asthenia, myalgia, and arthralgias. PPGSS has also been described as a manifestation of an underlying immunological mechanism that can be triggered by viral or drug-related antigens. A 32-year-old male developed a painful eruption on the bilateral hands and feet after being diagnosed with influenza B. On examination, scattered papular purpura with occasional overlying scale were noted on the bilateral hands, fingers, feet, toes, volar wrists, and ankles. Histopathologic sections showed a mixed pattern of inflammation with interface and spongiotic changes. A parakeratotic scale with overlying basket-weave orthokeratosis was also seen. Within the epidermis, there was intra-epidermal vesicles and Langerhans cell microabscess formation with scattered apoptotic keratinocytes. The underlying dermis showed a superficial perivascular lymphocytic infiltrate with mild edematous changes, and extravasation of red blood cells. Clinicopathologic correlation strongly supported a diagnosis of popular-purpuric gloves and socks syndrome. The influenza virus has never been reported in association with PPGSS; thus, this case outlines an important new variant that clinicians should be familiar with. This article is protected by copyright. All rights reserved.
Keywords: PPGSS; Papular-purpuric “gloves and socks” syndrome; gloves and socks syndrome.