tetano
Editor, Senior Moderator
J Diabetes Investig
. 2022 Jan 24.
doi: 10.1111/jdi.13754. Online ahead of print.
Impact of newly diagnosed diabetes on COVID-19 severity and hyperglycemia
Masaki Uchihara[SUP] 1 [/SUP], Ryotaro Bouchi[SUP] 1 2 [/SUP], Noriko Kodani[SUP] 1 [/SUP], Sho Saito[SUP] 3 [/SUP], Yusuke Miyazato[SUP] 3 [/SUP], Kotaro Umamoto[SUP] 1 [/SUP], Hirofumi Sugimoto[SUP] 1 [/SUP], Michi Kobayashi[SUP] 1 [/SUP], Sayaka Hikida[SUP] 3 [/SUP], Yutaro Akiyama[SUP] 3 [/SUP], Noriko Ihana-Sugiyama[SUP] 1 2 [/SUP], Mitsuru Osugi[SUP] 1 2 [/SUP], Akiyo Tanabe[SUP] 1 [/SUP], Kojiro Ueki[SUP] 1 4 [/SUP], Jin Takasaki[SUP] 3 5 [/SUP], Masayuki Hojo[SUP] 5 [/SUP], Hiroshi Kajio[SUP] 1 [/SUP]
Affiliations
Abstract
Aims/introduction: Diabetes is associated with poor clinical outcomes of coronavirus disease 2019 (COVID-19). However, the impact of newly diagnosed diabetes on prognosis has not been clarified. The objective of this study was to reveal the features and outcome of COVID-19 patients with newly diagnosed diabetes in Japan.
Materials and methods: We retrospectively analyzed 62 patients with diabetes hospitalized for COVID-19 between April 1 and August 18, 2021, at the National Center for Global Health and Medicine in Tokyo, Japan. We evaluated the worst severity of COVID-19 and plasma blood glucose levels in patients with newly diagnosed diabetes or pre-existing diabetes.
Results: This study included 62 confirmed COVID-19 patients with diabetes, including 19 (30.6%) patients with newly diagnosed diabetes and 43 (69.4%) patients with pre-existing diabetes. Patients with newly diagnosed diabetes significantly progressed to a critical condition more frequently during hospitalization than patients with pre-existing diabetes (52.6% vs. 20.9%, p = 0.018). In addition, patients with newly diagnosed diabetes had significantly higher average plasma blood glucose levels for the first 3 days after admission than those with pre-existing diabetes.
Conclusions: Our study suggests that the proportion of COVID-19 patients who are newly diagnosed with diabetes is high, and they have an increased risk of developing severe disease than those with pre-existing diabetes. It may be advisable that at the point of COVID-19 diagnosis, blood glucose and HbA1c levels be assessed in all patients.
Keywords: COVID-19; diabetes; hyperglycemia.
. 2022 Jan 24.
doi: 10.1111/jdi.13754. Online ahead of print.
Impact of newly diagnosed diabetes on COVID-19 severity and hyperglycemia
Masaki Uchihara[SUP] 1 [/SUP], Ryotaro Bouchi[SUP] 1 2 [/SUP], Noriko Kodani[SUP] 1 [/SUP], Sho Saito[SUP] 3 [/SUP], Yusuke Miyazato[SUP] 3 [/SUP], Kotaro Umamoto[SUP] 1 [/SUP], Hirofumi Sugimoto[SUP] 1 [/SUP], Michi Kobayashi[SUP] 1 [/SUP], Sayaka Hikida[SUP] 3 [/SUP], Yutaro Akiyama[SUP] 3 [/SUP], Noriko Ihana-Sugiyama[SUP] 1 2 [/SUP], Mitsuru Osugi[SUP] 1 2 [/SUP], Akiyo Tanabe[SUP] 1 [/SUP], Kojiro Ueki[SUP] 1 4 [/SUP], Jin Takasaki[SUP] 3 5 [/SUP], Masayuki Hojo[SUP] 5 [/SUP], Hiroshi Kajio[SUP] 1 [/SUP]
Affiliations
- PMID: 35075818
- DOI: 10.1111/jdi.13754
Abstract
Aims/introduction: Diabetes is associated with poor clinical outcomes of coronavirus disease 2019 (COVID-19). However, the impact of newly diagnosed diabetes on prognosis has not been clarified. The objective of this study was to reveal the features and outcome of COVID-19 patients with newly diagnosed diabetes in Japan.
Materials and methods: We retrospectively analyzed 62 patients with diabetes hospitalized for COVID-19 between April 1 and August 18, 2021, at the National Center for Global Health and Medicine in Tokyo, Japan. We evaluated the worst severity of COVID-19 and plasma blood glucose levels in patients with newly diagnosed diabetes or pre-existing diabetes.
Results: This study included 62 confirmed COVID-19 patients with diabetes, including 19 (30.6%) patients with newly diagnosed diabetes and 43 (69.4%) patients with pre-existing diabetes. Patients with newly diagnosed diabetes significantly progressed to a critical condition more frequently during hospitalization than patients with pre-existing diabetes (52.6% vs. 20.9%, p = 0.018). In addition, patients with newly diagnosed diabetes had significantly higher average plasma blood glucose levels for the first 3 days after admission than those with pre-existing diabetes.
Conclusions: Our study suggests that the proportion of COVID-19 patients who are newly diagnosed with diabetes is high, and they have an increased risk of developing severe disease than those with pre-existing diabetes. It may be advisable that at the point of COVID-19 diagnosis, blood glucose and HbA1c levels be assessed in all patients.
Keywords: COVID-19; diabetes; hyperglycemia.