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J Epidemiol Glob Health . Long COVID-19 and Coexistence of Fatigue and Depression: A Cross-sectional Study from Saudi Arabia

tetano

Editor, Senior Moderator
J Epidemiol Glob Health


. 2024 Oct 14.
doi: 10.1007/s44197-024-00312-7. Online ahead of print. Long COVID-19 and Coexistence of Fatigue and Depression: A Cross-sectional Study from Saudi Arabia

Abdulrahman Alharbi[SUP] 1 [/SUP], Faisal Almogbel[SUP] 2 [/SUP], Unaib Rabbani[SUP] 2 [/SUP], Ziad A Memish[SUP] 3 4 [/SUP]



Affiliations
Abstract

Background and objectives: Coronavirus disease 2019 (COVID-19) is associated with various manifestations even after infection resolution. This study aimed to assess the prevalence of post-COVID-19 fatigue and its predictors.
Methods: We conducted a nationwide cross-sectional study among Polymerase Chain Reaction test confirmed COVID-19 cases in Saudi Arabia from July 2021 to February 2022. We collected data through telephonic interviews covering socio-demographics, comorbidities, body mass index, smoking, illness severity, and COVID-19 vaccination status. We assessed fatigue using Fatigue Severity Scale while depression was assessed using Patient Health Questionnaire-2. Logistic regression was employed to analyze the relationship between post-COVID-19 fatigue and depression.
Results: The analysis included 361 participants with a mean age of 37 ± 10.5 years, among whom 43% were female. Approximately 10% had comorbidities, and 21% were current smokers. Nearly two-thirds (68%) of the participants reported mild illness. The prevalence of perceived fatigue was 22.7%, while fatigue measured by the Fatigue Severity Scale was 14.4%. The multivariable logistic regression model revealed that COVID-19 severity and depression were significant predictors of post-COVID-19 fatigue; adjusted odds ratio 1.87 (95% CI: 1.10 to 3.18) and 14.3 (95% CI: 4.55 to 45.0), respectively.
Conclusion: Our findings suggest a higher prevalence of perceived fatigue compared to that measured by the Fatigue Severity Scale, underscoring the importance of using a valid assessment tool for fatigue among COVID-19 patients to ensure proper management. The significant association between post-COVID-19 fatigue and depression highlights the need for psychological assessment of COVID-19 patients to enhance their post-infection quality of life.

Keywords: COVID-19; Fatigue; Long COVID-19; Mental health; Saudi arabia.

 
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