tetano
Editor, Senior Moderator
J Exp Med. 2020 Jun 1;217(6). pii: e20200652. doi: 10.1084/jem.20200652.
Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
Barnes BJ[SUP]1[/SUP], Adrover JM[SUP]2[/SUP], Baxter-Stoltzfus A[SUP]3[/SUP], Borczuk A[SUP]3[/SUP], Cools-Lartigue J[SUP]4[/SUP], Crawford JM[SUP]5[/SUP], Da?ler-Plenker J[SUP]2[/SUP], Guerci P[SUP]6[/SUP], Huynh C[SUP]4,[/SUP][SUP]7[/SUP], Knight JS[SUP]8[/SUP], Loda M[SUP]3[/SUP], Looney MR[SUP]9[/SUP], McAllister F[SUP]10[/SUP], Rayes R[SUP]4,[/SUP][SUP]7[/SUP], Renaud S[SUP]6[/SUP], Rousseau S[SUP]11[/SUP], Salvatore S[SUP]3[/SUP], Schwartz RE[SUP]12[/SUP], Spicer JD[SUP]4,[/SUP][SUP]7[/SUP], Yost CC[SUP]13[/SUP], Weber A[SUP]14[/SUP], Zuo Y[SUP]8[/SUP], Egeblad M[SUP]2[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
? 2020 Barnes et al.
PMID:32302401DOI:10.1084/jem.20200652
Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
Barnes BJ[SUP]1[/SUP], Adrover JM[SUP]2[/SUP], Baxter-Stoltzfus A[SUP]3[/SUP], Borczuk A[SUP]3[/SUP], Cools-Lartigue J[SUP]4[/SUP], Crawford JM[SUP]5[/SUP], Da?ler-Plenker J[SUP]2[/SUP], Guerci P[SUP]6[/SUP], Huynh C[SUP]4,[/SUP][SUP]7[/SUP], Knight JS[SUP]8[/SUP], Loda M[SUP]3[/SUP], Looney MR[SUP]9[/SUP], McAllister F[SUP]10[/SUP], Rayes R[SUP]4,[/SUP][SUP]7[/SUP], Renaud S[SUP]6[/SUP], Rousseau S[SUP]11[/SUP], Salvatore S[SUP]3[/SUP], Schwartz RE[SUP]12[/SUP], Spicer JD[SUP]4,[/SUP][SUP]7[/SUP], Yost CC[SUP]13[/SUP], Weber A[SUP]14[/SUP], Zuo Y[SUP]8[/SUP], Egeblad M[SUP]2[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
? 2020 Barnes et al.
PMID:32302401DOI:10.1084/jem.20200652