tetano
Editor, Senior Moderator
J Gen Virol
. 2023 Nov;104(11).
doi: 10.1099/jgv.0.001920. Evolution of the coronavirus spike protein in the full-length genome and defective viral genome under diverse selection pressures
Ching-Hung Lin[SUP] 1 [/SUP], Hon-Man-Herman Tam[SUP] 2 [/SUP], Cheng-Yao Yang[SUP] 1 [/SUP], Feng-Cheng Hsieh[SUP] 1 [/SUP], Jiun-Long Wang[SUP] 3 4 5 [/SUP], Chun-Chun Yang[SUP] 1 [/SUP], Hsuan-Wei Hsu[SUP] 1 [/SUP], Hao-Ping Liu[SUP] 2 [/SUP], Hung-Yi Wu[SUP] 1 [/SUP]
Affiliations
How coronaviruses evolve by altering the structures of their full-length genome and defective viral genome (DVG) under dynamic selection pressures has not been studied. In this study, we aimed to experimentally identify the dynamic evolutionary patterns of the S protein sequence in the full-length genome and DVG under diverse selection pressures, including persistence, innate immunity and antiviral drugs. The evolutionary features of the S protein sequence in the full-length genome and in the DVG under diverse selection pressures are as follows: (i) the number of nucleotide (nt) mutations does not necessarily increase with the number of selection pressures; (ii) certain types of selection pressure(s) can lead to specific nt mutations; (iii) the mutated nt sequence can be reverted to the wild-type nt sequence under the certain type of selection pressure(s); (iv) the DVG can also undergo mutations and evolve independently of the full-length genome; and (v) DVG species are regulated during evolution under diverse selection pressures. The various evolutionary patterns of the S protein sequence in the full-length genome and DVG identified in this study may contribute to coronaviral fitness under diverse selection pressures.
Keywords: coronavirus; defective viral genome; evolution; selection pressure; spike protein.
. 2023 Nov;104(11).
doi: 10.1099/jgv.0.001920. Evolution of the coronavirus spike protein in the full-length genome and defective viral genome under diverse selection pressures
Ching-Hung Lin[SUP] 1 [/SUP], Hon-Man-Herman Tam[SUP] 2 [/SUP], Cheng-Yao Yang[SUP] 1 [/SUP], Feng-Cheng Hsieh[SUP] 1 [/SUP], Jiun-Long Wang[SUP] 3 4 5 [/SUP], Chun-Chun Yang[SUP] 1 [/SUP], Hsuan-Wei Hsu[SUP] 1 [/SUP], Hao-Ping Liu[SUP] 2 [/SUP], Hung-Yi Wu[SUP] 1 [/SUP]
Affiliations
- PMID: 37997889
- DOI: 10.1099/jgv.0.001920
How coronaviruses evolve by altering the structures of their full-length genome and defective viral genome (DVG) under dynamic selection pressures has not been studied. In this study, we aimed to experimentally identify the dynamic evolutionary patterns of the S protein sequence in the full-length genome and DVG under diverse selection pressures, including persistence, innate immunity and antiviral drugs. The evolutionary features of the S protein sequence in the full-length genome and in the DVG under diverse selection pressures are as follows: (i) the number of nucleotide (nt) mutations does not necessarily increase with the number of selection pressures; (ii) certain types of selection pressure(s) can lead to specific nt mutations; (iii) the mutated nt sequence can be reverted to the wild-type nt sequence under the certain type of selection pressure(s); (iv) the DVG can also undergo mutations and evolve independently of the full-length genome; and (v) DVG species are regulated during evolution under diverse selection pressures. The various evolutionary patterns of the S protein sequence in the full-length genome and DVG identified in this study may contribute to coronaviral fitness under diverse selection pressures.
Keywords: coronavirus; defective viral genome; evolution; selection pressure; spike protein.