tetano
Editor, Senior Moderator
J Gerontol A Biol Sci Med Sci
. 2020 Aug 26;glaa210.
doi: 10.1093/gerona/glaa210. Online ahead of print.
Clinical Characteristics and Outcomes of 821 Older Patients with SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards
Lor?ne Zerah[SUP] 1 2 [/SUP], ?douard Baudouin[SUP] 1 [/SUP], Marion P?pin[SUP] 3 4 [/SUP], Morgane Mary[SUP] 5 [/SUP], S?bastien Krypciak[SUP] 6 7 [/SUP], C?line Bianco[SUP] 8 9 [/SUP], Swasti Roux[SUP] 10 [/SUP], Ariane Gross[SUP] 11 [/SUP], Charlotte Tom?o[SUP] 1 [/SUP], Nad?ge Lemari?[SUP] 12 [/SUP], Antoine Dureau[SUP] 13 [/SUP], Sophie Bastiani[SUP] 14 [/SUP], Flora Ketz[SUP] 15 [/SUP], Cl?mence Boully[SUP] 16 17 [/SUP], C?dric de Villelongue[SUP] 18 [/SUP], Mouna Romdhani[SUP] 19 [/SUP], Marie-Astrid Desoutter[SUP] 3 4 [/SUP], Emmanuelle Duron[SUP] 5 20 [/SUP], Jean-Philippe David[SUP] 6 7 [/SUP], Caroline Thomas[SUP] 8 [/SUP], Elena Paillaud[SUP] 7 21 [/SUP], Pauline de Malglaive[SUP] 11 [/SUP], Eric Bouvard[SUP] 12 [/SUP], Mathilde Lacrampe[SUP] 13 [/SUP], Elise Mercadier[SUP] 14 [/SUP], Alexandra Monti[SUP] 15 [/SUP], Olivier Hanon[SUP] 16 17 [/SUP], Virginie Fossey-Diaz[SUP] 18 [/SUP], Lauriane Bourdonnec[SUP] 19 [/SUP], Bruno Riou[SUP] 22 23 [/SUP], H?l?ne Vallet[SUP] 8 9 [/SUP], Jacques Boddaert[SUP] 1 9 [/SUP], APHP / Universities / Inserm COVID-19 research collaboration
Affiliations
Abstract
Background: There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19).
Methods: We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March 13 to April 15, 2020, in Paris area. All consecutive patients aged ≥ 70 years, with confirmed COVID-19, were enrolled.
Results: Of the 821 patients included in the study, the mean (SD) age was 86 (7) years; 58% were female; 85% had ≥ 2 comorbidities; 29% lived in an institution; and the median (interquartile range) Activities of Daily Living Scale (ADL) score was 4 [2-6]. The most common symptoms at COVID-19 onset were asthenia (63%), fever (55%), dyspnea (45%), dry cough (45%) and delirium (25%). The in-hospital mortality was 31% (95% confidence interval [CI], 27 to 33). On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR], 1.85; 95% CI, 1.30 to 2.63), ADL score < 4 (OR, 1.84; 95% CI, 1.25 to 2.70), asthenia (OR, 1.59; 95% CI, 1.08 to 2.32), quick Sequential Organ Failure Assessment score ≥ 2 (OR, 2.63; 95% CI, 1.64 to 4.22) and specific COVID-19 anomalies on chest computerized tomography (OR, 2.60; 95% CI, 1.07 to 6.46).
Conclusions: This study provides new information about older patients with COVID-19 who are hospitalized. A quick bedside evaluation at admission of sex, functional status, systolic arterial pressure, consciousness, respiratory rate and asthenia can identify older patients at risk of unfavorable outcomes.
Keywords: COVID-19; geriatrics; in-hospital mortality.
. 2020 Aug 26;glaa210.
doi: 10.1093/gerona/glaa210. Online ahead of print.
Clinical Characteristics and Outcomes of 821 Older Patients with SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards
Lor?ne Zerah[SUP] 1 2 [/SUP], ?douard Baudouin[SUP] 1 [/SUP], Marion P?pin[SUP] 3 4 [/SUP], Morgane Mary[SUP] 5 [/SUP], S?bastien Krypciak[SUP] 6 7 [/SUP], C?line Bianco[SUP] 8 9 [/SUP], Swasti Roux[SUP] 10 [/SUP], Ariane Gross[SUP] 11 [/SUP], Charlotte Tom?o[SUP] 1 [/SUP], Nad?ge Lemari?[SUP] 12 [/SUP], Antoine Dureau[SUP] 13 [/SUP], Sophie Bastiani[SUP] 14 [/SUP], Flora Ketz[SUP] 15 [/SUP], Cl?mence Boully[SUP] 16 17 [/SUP], C?dric de Villelongue[SUP] 18 [/SUP], Mouna Romdhani[SUP] 19 [/SUP], Marie-Astrid Desoutter[SUP] 3 4 [/SUP], Emmanuelle Duron[SUP] 5 20 [/SUP], Jean-Philippe David[SUP] 6 7 [/SUP], Caroline Thomas[SUP] 8 [/SUP], Elena Paillaud[SUP] 7 21 [/SUP], Pauline de Malglaive[SUP] 11 [/SUP], Eric Bouvard[SUP] 12 [/SUP], Mathilde Lacrampe[SUP] 13 [/SUP], Elise Mercadier[SUP] 14 [/SUP], Alexandra Monti[SUP] 15 [/SUP], Olivier Hanon[SUP] 16 17 [/SUP], Virginie Fossey-Diaz[SUP] 18 [/SUP], Lauriane Bourdonnec[SUP] 19 [/SUP], Bruno Riou[SUP] 22 23 [/SUP], H?l?ne Vallet[SUP] 8 9 [/SUP], Jacques Boddaert[SUP] 1 9 [/SUP], APHP / Universities / Inserm COVID-19 research collaboration
Affiliations
- PMID: 32845301
- DOI: 10.1093/gerona/glaa210
Abstract
Background: There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19).
Methods: We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March 13 to April 15, 2020, in Paris area. All consecutive patients aged ≥ 70 years, with confirmed COVID-19, were enrolled.
Results: Of the 821 patients included in the study, the mean (SD) age was 86 (7) years; 58% were female; 85% had ≥ 2 comorbidities; 29% lived in an institution; and the median (interquartile range) Activities of Daily Living Scale (ADL) score was 4 [2-6]. The most common symptoms at COVID-19 onset were asthenia (63%), fever (55%), dyspnea (45%), dry cough (45%) and delirium (25%). The in-hospital mortality was 31% (95% confidence interval [CI], 27 to 33). On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR], 1.85; 95% CI, 1.30 to 2.63), ADL score < 4 (OR, 1.84; 95% CI, 1.25 to 2.70), asthenia (OR, 1.59; 95% CI, 1.08 to 2.32), quick Sequential Organ Failure Assessment score ≥ 2 (OR, 2.63; 95% CI, 1.64 to 4.22) and specific COVID-19 anomalies on chest computerized tomography (OR, 2.60; 95% CI, 1.07 to 6.46).
Conclusions: This study provides new information about older patients with COVID-19 who are hospitalized. A quick bedside evaluation at admission of sex, functional status, systolic arterial pressure, consciousness, respiratory rate and asthenia can identify older patients at risk of unfavorable outcomes.
Keywords: COVID-19; geriatrics; in-hospital mortality.