tetano
Editor, Senior Moderator
J Glob Health
. 2023 Jul 14;13:06027.
doi: 10.7189/jogh.13.06027. Causal relationship between particulate matter 2.5 (PM[SUB]2.5[/SUB]), PM[SUB]2.5[/SUB] absorbance, and COVID-19 risk: A two-sample Mendelian randomisation study
Chenxi Liu[SUP] 1 2 [/SUP], Jia Peng[SUP] 1 2 [/SUP], Yubo Liu[SUP] 1 2 [/SUP], Yi Peng[SUP] 2 3 [/SUP], Yuanyuan Kuang[SUP] 1 [/SUP], Yinzhuang Zhang[SUP] 4 [/SUP], Qilin Ma[SUP] 1 2 [/SUP]
Affiliations
Background: Several observational studies reported on the association between particulate matter ≤2.5μm (PM[SUB]2.5[/SUB]) and its absorbance with coronavirus (COVID-19), but none use Mendelian randomisation (MR). To strengthen the knowledge on causality, we examined the association of PM[SUB]2.5[/SUB] and its absorbance with COVID-19 risk using MR.
Methods: We selected genome-wide association study (GWAS) integration data from the UK Biobank and IEU Open GWAS Project for two-sample MR analysis. We used inverse variance weighted (IVW) and its multiple random effects and fixed effects alternatives to generally predict the association of PM[SUB]2.5[/SUB] and its absorbance with COVID-19, and six methods (MR Egger, weighted median, simple mode, weighted mode, maximum-likelihood and MR-PRESSO) as complementary analyses.
Results: MR results suggested that PM[SUB]2.5[/SUB] absorbance was associated with COVID-19 infection (odds ratio (OR) = 2.64; 95% confidence interval (CI) = 1.32-5.27, P = 0.006), hospitalisation (OR = 3.52; 95% CI = 1.05-11.75, P = 0.041) and severe respiratory symptoms (OR = 28.74; 95% CI = 4.00-206.32, P = 0.001) in IVW methods. We observed no association between PM[SUB]2.5[/SUB] and COVID-19.
Conclusions: We found a potential causal association of PM[SUB]2.5[/SUB] absorbance with COVID-19 infection, hospitalisation, and severe respiratory symptoms using MR analysis. Prevention and control of air pollution could help delay and halt the negative progression of COVID-19.
. 2023 Jul 14;13:06027.
doi: 10.7189/jogh.13.06027. Causal relationship between particulate matter 2.5 (PM[SUB]2.5[/SUB]), PM[SUB]2.5[/SUB] absorbance, and COVID-19 risk: A two-sample Mendelian randomisation study
Chenxi Liu[SUP] 1 2 [/SUP], Jia Peng[SUP] 1 2 [/SUP], Yubo Liu[SUP] 1 2 [/SUP], Yi Peng[SUP] 2 3 [/SUP], Yuanyuan Kuang[SUP] 1 [/SUP], Yinzhuang Zhang[SUP] 4 [/SUP], Qilin Ma[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37449380
- DOI: 10.7189/jogh.13.06027
Background: Several observational studies reported on the association between particulate matter ≤2.5μm (PM[SUB]2.5[/SUB]) and its absorbance with coronavirus (COVID-19), but none use Mendelian randomisation (MR). To strengthen the knowledge on causality, we examined the association of PM[SUB]2.5[/SUB] and its absorbance with COVID-19 risk using MR.
Methods: We selected genome-wide association study (GWAS) integration data from the UK Biobank and IEU Open GWAS Project for two-sample MR analysis. We used inverse variance weighted (IVW) and its multiple random effects and fixed effects alternatives to generally predict the association of PM[SUB]2.5[/SUB] and its absorbance with COVID-19, and six methods (MR Egger, weighted median, simple mode, weighted mode, maximum-likelihood and MR-PRESSO) as complementary analyses.
Results: MR results suggested that PM[SUB]2.5[/SUB] absorbance was associated with COVID-19 infection (odds ratio (OR) = 2.64; 95% confidence interval (CI) = 1.32-5.27, P = 0.006), hospitalisation (OR = 3.52; 95% CI = 1.05-11.75, P = 0.041) and severe respiratory symptoms (OR = 28.74; 95% CI = 4.00-206.32, P = 0.001) in IVW methods. We observed no association between PM[SUB]2.5[/SUB] and COVID-19.
Conclusions: We found a potential causal association of PM[SUB]2.5[/SUB] absorbance with COVID-19 infection, hospitalisation, and severe respiratory symptoms using MR analysis. Prevention and control of air pollution could help delay and halt the negative progression of COVID-19.