tetano
Editor, Senior Moderator
J Hazard Mater
. 2022 Feb 4;430:128414.
doi: 10.1016/j.jhazmat.2022.128414. Online ahead of print.
Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
Hongbo Qin[SUP] 1 [/SUP], Hengju Qiu[SUP] 2 [/SUP], Shi-Ting He[SUP] 3 [/SUP], Bixia Hong[SUP] 3 [/SUP], Ke Liu[SUP] 3 [/SUP], Fuxing Lou[SUP] 3 [/SUP], Maochen Li[SUP] 3 [/SUP], Pan Hu[SUP] 2 [/SUP], Xianghao Kong[SUP] 2 [/SUP], Yujie Song[SUP] 2 [/SUP], Yuchen Liu[SUP] 2 [/SUP], Mingfang Pu[SUP] 3 [/SUP], Pengjun Han[SUP] 3 [/SUP], Mengzhe Li[SUP] 3 [/SUP], Xiaoping An[SUP] 3 [/SUP], Lihua Song[SUP] 3 [/SUP], Yigang Tong[SUP] 4 [/SUP], Huahao Fan[SUP] 5 [/SUP], Ruixue Wang[SUP] 6 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (CAP), a novel sterilization strategy, was found to potently inactivate SARS-CoV-2-like coronavirus GX_P2V, six strains of major epidemic SARS-CoV-2 variants and even swine coronavirus PEDV and SADS-CoV within 300 s (with inhibition rate more than 99%). We identified four dominant short-lived reactive species, ONOO[SUP]-[/SUP], [SUP]1[/SUP]O[SUB]2[/SUB], O[SUB]2[/SUB][SUP]-[/SUP] and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). Our study provides detailed evidence of a novel surface disinfection strategy for SARS-CoV-2 and other coronaviruses.
Keywords: Cold pressure plasma; Coronavirus; Peroxynitrite anion; Pseudotyped variants; SARS-CoV-2; Short-lived reactive species.
. 2022 Feb 4;430:128414.
doi: 10.1016/j.jhazmat.2022.128414. Online ahead of print.
Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
Hongbo Qin[SUP] 1 [/SUP], Hengju Qiu[SUP] 2 [/SUP], Shi-Ting He[SUP] 3 [/SUP], Bixia Hong[SUP] 3 [/SUP], Ke Liu[SUP] 3 [/SUP], Fuxing Lou[SUP] 3 [/SUP], Maochen Li[SUP] 3 [/SUP], Pan Hu[SUP] 2 [/SUP], Xianghao Kong[SUP] 2 [/SUP], Yujie Song[SUP] 2 [/SUP], Yuchen Liu[SUP] 2 [/SUP], Mingfang Pu[SUP] 3 [/SUP], Pengjun Han[SUP] 3 [/SUP], Mengzhe Li[SUP] 3 [/SUP], Xiaoping An[SUP] 3 [/SUP], Lihua Song[SUP] 3 [/SUP], Yigang Tong[SUP] 4 [/SUP], Huahao Fan[SUP] 5 [/SUP], Ruixue Wang[SUP] 6 [/SUP]
Affiliations
- PMID: 35149493
- DOI: 10.1016/j.jhazmat.2022.128414
Abstract
Coronavirus disease 2019 (COVID-19) has become a worldwide public health emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns. Efficient disinfection methods are crucial for the prevention of viral transmission. Herein, pulse power-driven cold atmospheric plasma (CAP), a novel sterilization strategy, was found to potently inactivate SARS-CoV-2-like coronavirus GX_P2V, six strains of major epidemic SARS-CoV-2 variants and even swine coronavirus PEDV and SADS-CoV within 300 s (with inhibition rate more than 99%). We identified four dominant short-lived reactive species, ONOO[SUP]-[/SUP], [SUP]1[/SUP]O[SUB]2[/SUB], O[SUB]2[/SUB][SUP]-[/SUP] and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). Our study provides detailed evidence of a novel surface disinfection strategy for SARS-CoV-2 and other coronaviruses.
Keywords: Cold pressure plasma; Coronavirus; Peroxynitrite anion; Pseudotyped variants; SARS-CoV-2; Short-lived reactive species.