tetano
Editor, Senior Moderator
J Hematop
. 2020 Oct 8;1-10.
doi: 10.1007/s12308-020-00419-3. Online ahead of print.
Elevated eosinophil count is related with lower anti-factor Xa activity in COVID-19 patients
Selma Ari[SUP] 1 [/SUP], Veysi Can[SUP] 1 [/SUP], ?mer Furkan Demir[SUP] 1 [/SUP], Hasan Ari[SUP] 1 [/SUP], Fahriye Vatansever Ağca[SUP] 1 [/SUP], Mehmet Melek[SUP] 1 [/SUP], Sencer ?amci[SUP] 1 [/SUP], ?zlem Şeng?ren Dikiş[SUP] 2 [/SUP], Kağan Huysal[SUP] 3 [/SUP], Tamer T?rk[SUP] 4 [/SUP]
Affiliations
Abstract
Despite prophylactic anticoagulant treatments, thrombotic complications may develop in patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the factors influencing anti-factor Xa activity in COVID-19 patients receiving low molecular weight heparin (LMWH). We prospectively evaluated 80 COVID-19 patients, diagnosed using polymerase chain reaction test, who were admitted to our clinic and administered LMWH; LMWH (enoxaparin) was applied according to the weight, D-dimer levels, and clinical condition of patients. Anti-factor Xa activity in blood, drawn 4 h after the 3rd dose of LMWH, was measured and an activity of < 0.2 IU/mL was considered subprophylactic. Patients were followed up clinically, and anti-factor Xa activity was re-examined before discharge. Groups 1 and 2 included 13 and 67 patients with subprophylactic (mean ? SD: 0.18 ? 0.06) and prophylactic (mean ? SD: 0.43 ? 0.23) anti-factor Xa activity, respectively. The proportion of eosinophils in patients was significantly higher in group 1 than in group 2 (mean ? SD; 2.96 ? 2.55 vs 0.90 ? 1.28; p = 0.001). At the time of discharge, the eosinophilic proportion of patients was significantly higher (eosinophil %, mean ? SD; 3.06 ? 1.49 vs 2.07 ? 1.92; p = 0.001), but the activated partial thromboplastin time was significantly lower (22.34 ? 1.38 vs 24.38 ? 3.58; p = 0.01) in group 1 than in group 2. Of 14 patients with eosinophil content > 4%, 6 were in group 1 ((6/13) 46.2%), while 8 were in group 2 ((8/63) 11.9%); (p = 0.009), and all had a D-dimer level < 1 μg/mL (p = 0.03). ROC analysis for the presence of anticoagulation at subprophylactic level revealed an area under curve of 0.79 (95% CI: 0.64-0.93); p = 0.001). In conclusion; Elevated eosinophil count is related to lower anti-factor Xa activity in patients with COVID-19 receiving LMWH. The clinical significance of the subprophylactic anti-factor Xa activity should be studied in COVID-19 patients (NCT04507282).
Keywords: Anticoagulants; COVID-19; Eosinophils; Heparin; Thrombosis.
. 2020 Oct 8;1-10.
doi: 10.1007/s12308-020-00419-3. Online ahead of print.
Elevated eosinophil count is related with lower anti-factor Xa activity in COVID-19 patients
Selma Ari[SUP] 1 [/SUP], Veysi Can[SUP] 1 [/SUP], ?mer Furkan Demir[SUP] 1 [/SUP], Hasan Ari[SUP] 1 [/SUP], Fahriye Vatansever Ağca[SUP] 1 [/SUP], Mehmet Melek[SUP] 1 [/SUP], Sencer ?amci[SUP] 1 [/SUP], ?zlem Şeng?ren Dikiş[SUP] 2 [/SUP], Kağan Huysal[SUP] 3 [/SUP], Tamer T?rk[SUP] 4 [/SUP]
Affiliations
- PMID: 33046998
- PMCID: PMC7541761
- DOI: 10.1007/s12308-020-00419-3
Abstract
Despite prophylactic anticoagulant treatments, thrombotic complications may develop in patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the factors influencing anti-factor Xa activity in COVID-19 patients receiving low molecular weight heparin (LMWH). We prospectively evaluated 80 COVID-19 patients, diagnosed using polymerase chain reaction test, who were admitted to our clinic and administered LMWH; LMWH (enoxaparin) was applied according to the weight, D-dimer levels, and clinical condition of patients. Anti-factor Xa activity in blood, drawn 4 h after the 3rd dose of LMWH, was measured and an activity of < 0.2 IU/mL was considered subprophylactic. Patients were followed up clinically, and anti-factor Xa activity was re-examined before discharge. Groups 1 and 2 included 13 and 67 patients with subprophylactic (mean ? SD: 0.18 ? 0.06) and prophylactic (mean ? SD: 0.43 ? 0.23) anti-factor Xa activity, respectively. The proportion of eosinophils in patients was significantly higher in group 1 than in group 2 (mean ? SD; 2.96 ? 2.55 vs 0.90 ? 1.28; p = 0.001). At the time of discharge, the eosinophilic proportion of patients was significantly higher (eosinophil %, mean ? SD; 3.06 ? 1.49 vs 2.07 ? 1.92; p = 0.001), but the activated partial thromboplastin time was significantly lower (22.34 ? 1.38 vs 24.38 ? 3.58; p = 0.01) in group 1 than in group 2. Of 14 patients with eosinophil content > 4%, 6 were in group 1 ((6/13) 46.2%), while 8 were in group 2 ((8/63) 11.9%); (p = 0.009), and all had a D-dimer level < 1 μg/mL (p = 0.03). ROC analysis for the presence of anticoagulation at subprophylactic level revealed an area under curve of 0.79 (95% CI: 0.64-0.93); p = 0.001). In conclusion; Elevated eosinophil count is related to lower anti-factor Xa activity in patients with COVID-19 receiving LMWH. The clinical significance of the subprophylactic anti-factor Xa activity should be studied in COVID-19 patients (NCT04507282).
Keywords: Anticoagulants; COVID-19; Eosinophils; Heparin; Thrombosis.