tetano
Editor, Senior Moderator
J Infect Chemother
. 2020 Oct 10;S1341-321X(20)30370-6.
doi: 10.1016/j.jiac.2020.10.011. Online ahead of print.
A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
Takatomo Hirouchi[SUP] 1 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Dai Mashima[SUP] 3 [/SUP], Ryuichi Boku[SUP] 4 [/SUP], Yuto Yoshida[SUP] 1 [/SUP], Koki Iwata[SUP] 4 [/SUP], Kanako Shinada[SUP] 1 [/SUP], Takashi Matsumoto[SUP] 4 [/SUP], Miwa Morikawa[SUP] 1 [/SUP], Takashi Sato[SUP] 1 [/SUP], Masahiro Shinoda[SUP] 1 [/SUP], Kenichi Kamachi[SUP] 4 [/SUP], Masaharu Shinkai[SUP] 1 [/SUP]
Affiliations
Abstract
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.
Keywords: COVID-19; Favipiravir; Loop-mediated isothermal amplification (LAMP); Viremia.
. 2020 Oct 10;S1341-321X(20)30370-6.
doi: 10.1016/j.jiac.2020.10.011. Online ahead of print.
A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
Takatomo Hirouchi[SUP] 1 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Dai Mashima[SUP] 3 [/SUP], Ryuichi Boku[SUP] 4 [/SUP], Yuto Yoshida[SUP] 1 [/SUP], Koki Iwata[SUP] 4 [/SUP], Kanako Shinada[SUP] 1 [/SUP], Takashi Matsumoto[SUP] 4 [/SUP], Miwa Morikawa[SUP] 1 [/SUP], Takashi Sato[SUP] 1 [/SUP], Masahiro Shinoda[SUP] 1 [/SUP], Kenichi Kamachi[SUP] 4 [/SUP], Masaharu Shinkai[SUP] 1 [/SUP]
Affiliations
- PMID: 33268271
- DOI: 10.1016/j.jiac.2020.10.011
Abstract
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.
Keywords: COVID-19; Favipiravir; Loop-mediated isothermal amplification (LAMP); Viremia.