tetano
Editor, Senior Moderator
J Infect Chemother
. 2022 Feb 9;S1341-321X(22)00041-1.
doi: 10.1016/j.jiac.2022.02.002. Online ahead of print.
Investigation of the incidence of immunisation stress-related response following COVID-19 vaccination in healthcare workers
Tomonori Takano[SUP] 1 [/SUP], Masanori Hirose[SUP] 2 [/SUP], Yukitaka Yamasaki[SUP] 1 [/SUP], Masatoshi Hara[SUP] 3 [/SUP], Tomoyuki Okada[SUP] 4 [/SUP], Hiroyuki Kunishima[SUP] 5 [/SUP]
Affiliations
Abstract
Introduction: Safe vaccination worldwide is critical to end the coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate adverse reactions to vaccination using a web-based questionnaire and examine the risk factors for the occurrence of immunisation stress-related response (ISRR).
Methods: We conducted a questionnaire survey using Google Form® among the employees of St. Marianna University Hospital who had received the COVID-19 vaccine between April 2021 and May 2021, 1 week after the first and second vaccinations. We developed and used a questionnaire to identify individuals with ISRR according to the World Health Organization diagnostic criteria. A generalised linear mixed model was constructed with ISRR onset as the dependent variable, subjects as the random factor, and each parameter as a fixed factor. A multivariate model was constructed using the forced imputation method with factors that were significant in the univariate analysis.
Results: We enrolled 2,073 and 1,856 respondents in the first and second questionnaire surveys, respectively. Fifty-five and 33 ISRR cases were identified in the first and second vaccinations, respectively. In the univariate analysis, strong pre-vaccination anxiety (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.30-4.12, p = 0·004) and history of allergy (OR, 1.6; 95% CI, 1.14-2.24, p = 0·007) were significant risk factors. Multivariate analysis also showed that strong pre-vaccination anxiety (OR, 2.1; 95% CI, 1.15-3.80, p = 0.016) and history of allergy (OR, 1.5; 95% CI, 1.09-2.15, p = 0.014) were significant risk factors.
Conclusions: Confirmation of allergy prior to vaccination and subsequent action are essential for addressing ISRR.
Keywords: Adverse events following immunisation; Allergy; Anxiety-related response; Coronavirus disease 2019; Immunisation stress-related response; Vaccination.
. 2022 Feb 9;S1341-321X(22)00041-1.
doi: 10.1016/j.jiac.2022.02.002. Online ahead of print.
Investigation of the incidence of immunisation stress-related response following COVID-19 vaccination in healthcare workers
Tomonori Takano[SUP] 1 [/SUP], Masanori Hirose[SUP] 2 [/SUP], Yukitaka Yamasaki[SUP] 1 [/SUP], Masatoshi Hara[SUP] 3 [/SUP], Tomoyuki Okada[SUP] 4 [/SUP], Hiroyuki Kunishima[SUP] 5 [/SUP]
Affiliations
- PMID: 35190259
- DOI: 10.1016/j.jiac.2022.02.002
Abstract
Introduction: Safe vaccination worldwide is critical to end the coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate adverse reactions to vaccination using a web-based questionnaire and examine the risk factors for the occurrence of immunisation stress-related response (ISRR).
Methods: We conducted a questionnaire survey using Google Form® among the employees of St. Marianna University Hospital who had received the COVID-19 vaccine between April 2021 and May 2021, 1 week after the first and second vaccinations. We developed and used a questionnaire to identify individuals with ISRR according to the World Health Organization diagnostic criteria. A generalised linear mixed model was constructed with ISRR onset as the dependent variable, subjects as the random factor, and each parameter as a fixed factor. A multivariate model was constructed using the forced imputation method with factors that were significant in the univariate analysis.
Results: We enrolled 2,073 and 1,856 respondents in the first and second questionnaire surveys, respectively. Fifty-five and 33 ISRR cases were identified in the first and second vaccinations, respectively. In the univariate analysis, strong pre-vaccination anxiety (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.30-4.12, p = 0·004) and history of allergy (OR, 1.6; 95% CI, 1.14-2.24, p = 0·007) were significant risk factors. Multivariate analysis also showed that strong pre-vaccination anxiety (OR, 2.1; 95% CI, 1.15-3.80, p = 0.016) and history of allergy (OR, 1.5; 95% CI, 1.09-2.15, p = 0.014) were significant risk factors.
Conclusions: Confirmation of allergy prior to vaccination and subsequent action are essential for addressing ISRR.
Keywords: Adverse events following immunisation; Allergy; Anxiety-related response; Coronavirus disease 2019; Immunisation stress-related response; Vaccination.