tetano
Editor, Senior Moderator
J Infect Chemother
. 2022 Apr 22;S1341-321X(22)00132-5.
doi: 10.1016/j.jiac.2022.04.018. Online ahead of print.
Neutralising activity and antibody titre in 10 patients with breakthrough infections of the SARS-CoV-2 Omicron variant in Japan
Nobumasa Okumura[SUP] 1 [/SUP], Shinya Tsuzuki[SUP] 2 [/SUP], Sho Saito[SUP] 3 [/SUP], Shin-Ichiro Hattori[SUP] 4 [/SUP], Junko S Takeuchi[SUP] 5 [/SUP], Tomoya Saito[SUP] 6 [/SUP], Mugen Ujiie[SUP] 7 [/SUP], Masayuki Hojo[SUP] 7 [/SUP], Noriko Iwamoto[SUP] 1 [/SUP], Wataru Sugiura[SUP] 5 [/SUP], Hiroaki Mitsuya[SUP] 4 [/SUP], Norio Ohmagari[SUP] 8 [/SUP]
Affiliations
Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 has multiple amino acid mutations in its spike proteins, which may allow it to evade immunity elicited by vaccination. We examined the neutralising activity and S1-IgG titres in patients with breakthrough infections caused by the Omicron variant after two doses of vaccination. We found that neutralising activity was significantly lower for the Omicron variant than for the Wuhan strain. Two doses of vaccination might not induce sufficient neutralising activity for the Omicron variant.
Keywords: Antibody titre; Breakthrough infection; Coronavirus disease 2019 (COVID-19); Neutralising activity; Omicron.
. 2022 Apr 22;S1341-321X(22)00132-5.
doi: 10.1016/j.jiac.2022.04.018. Online ahead of print.
Neutralising activity and antibody titre in 10 patients with breakthrough infections of the SARS-CoV-2 Omicron variant in Japan
Nobumasa Okumura[SUP] 1 [/SUP], Shinya Tsuzuki[SUP] 2 [/SUP], Sho Saito[SUP] 3 [/SUP], Shin-Ichiro Hattori[SUP] 4 [/SUP], Junko S Takeuchi[SUP] 5 [/SUP], Tomoya Saito[SUP] 6 [/SUP], Mugen Ujiie[SUP] 7 [/SUP], Masayuki Hojo[SUP] 7 [/SUP], Noriko Iwamoto[SUP] 1 [/SUP], Wataru Sugiura[SUP] 5 [/SUP], Hiroaki Mitsuya[SUP] 4 [/SUP], Norio Ohmagari[SUP] 8 [/SUP]
Affiliations
- PMID: 35644734
- DOI: 10.1016/j.jiac.2022.04.018
Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 has multiple amino acid mutations in its spike proteins, which may allow it to evade immunity elicited by vaccination. We examined the neutralising activity and S1-IgG titres in patients with breakthrough infections caused by the Omicron variant after two doses of vaccination. We found that neutralising activity was significantly lower for the Omicron variant than for the Wuhan strain. Two doses of vaccination might not induce sufficient neutralising activity for the Omicron variant.
Keywords: Antibody titre; Breakthrough infection; Coronavirus disease 2019 (COVID-19); Neutralising activity; Omicron.