tetano
Editor, Senior Moderator
J Infect Chemother
. 2026 Oct 13:103101.
doi: 10.1016/j.jiac.2026.103101. Online ahead of print.
Shinichi Morimoto 1 , Maiko Nakashio 2 , Akihiro Fujita 3 , Junichi Maruyama 4 , Hiroko Okura 5 , Yoshito Izutani 6 , Kentaro Muranishi 7 , Atsuo Nakamura 8 , Yoshihiko Nakamura 9
Affiliations Expand
Purpose: Long-term multidomain impairment after critical coronavirus disease 2019 (COVID-19) overlaps with post-intensive care syndrome (PICS) and post-COVID-19 condition. We assessed PICS at 6 months and 1 year after hospital discharge and explored associated clinical factors in Japanese patients with COVID-19 requiring invasive mechanical ventilation.
Methods: This single-center observational study included adult patients with COVID-19 who required invasive mechanical ventilation and survived to discharge. PICS was assessed using the Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale. Exploratory multivariable logistic regression examined factors associated with 1-year PICS.
Results: Of 67 discharged survivors, 37 completed both 6-month and 1-year assessments; 17 (45.9%) received extracorporeal membrane oxygenation. PICS was present in 22 (59.5%) patients at 6 months and 21 (56.8%) at 1 year, and 15 (40.5%) had cognitive impairment at both assessments. Delirium was more frequent in patients with PICS than in those without at 6 months (63.6% vs 26.7%, p=0.045) and 1 year (66.7% vs 25.0%, p=0.020). In the exploratory multivariable analysis, delirium was associated with 1-year PICS after adjustment for age and mechanical ventilation duration (odds ratio, 7.09; 95% confidence interval, 1.54-32.7; p=0.012).
Conclusions: PICS was common 6 months and 1 year after hospital discharge among survivors of severe COVID-19. In an exploratory analysis, delirium was associated with 1-year PICS after adjustment for age and mechanical ventilation duration. This hypothesis-generating finding requires confirmation in larger prospective cohorts.
Keywords: COVID-19; delirium; invasive mechanical ventilation; long-term outcome; post-COVID-19 condition; post-intensive care syndrome.
. 2026 Oct 13:103101.
doi: 10.1016/j.jiac.2026.103101. Online ahead of print.
Post-intensive care syndrome at 6 months and 1 year among survivors of severe COVID-19 requiring invasive mechanical ventilation: a single-center observational study
Shinichi Morimoto 1 , Maiko Nakashio 2 , Akihiro Fujita 3 , Junichi Maruyama 4 , Hiroko Okura 5 , Yoshito Izutani 6 , Kentaro Muranishi 7 , Atsuo Nakamura 8 , Yoshihiko Nakamura 9
Affiliations Expand
- PMID: 42869181
- DOI: 10.1016/j.jiac.2026.103101
Abstract
Purpose: Long-term multidomain impairment after critical coronavirus disease 2019 (COVID-19) overlaps with post-intensive care syndrome (PICS) and post-COVID-19 condition. We assessed PICS at 6 months and 1 year after hospital discharge and explored associated clinical factors in Japanese patients with COVID-19 requiring invasive mechanical ventilation.
Methods: This single-center observational study included adult patients with COVID-19 who required invasive mechanical ventilation and survived to discharge. PICS was assessed using the Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale. Exploratory multivariable logistic regression examined factors associated with 1-year PICS.
Results: Of 67 discharged survivors, 37 completed both 6-month and 1-year assessments; 17 (45.9%) received extracorporeal membrane oxygenation. PICS was present in 22 (59.5%) patients at 6 months and 21 (56.8%) at 1 year, and 15 (40.5%) had cognitive impairment at both assessments. Delirium was more frequent in patients with PICS than in those without at 6 months (63.6% vs 26.7%, p=0.045) and 1 year (66.7% vs 25.0%, p=0.020). In the exploratory multivariable analysis, delirium was associated with 1-year PICS after adjustment for age and mechanical ventilation duration (odds ratio, 7.09; 95% confidence interval, 1.54-32.7; p=0.012).
Conclusions: PICS was common 6 months and 1 year after hospital discharge among survivors of severe COVID-19. In an exploratory analysis, delirium was associated with 1-year PICS after adjustment for age and mechanical ventilation duration. This hypothesis-generating finding requires confirmation in larger prospective cohorts.
Keywords: COVID-19; delirium; invasive mechanical ventilation; long-term outcome; post-COVID-19 condition; post-intensive care syndrome.