tetano
Editor, Senior Moderator
J Infect Chemother
. 2021 Mar 11;S1341-321X(21)00081-7.
doi: 10.1016/j.jiac.2021.03.007. Online ahead of print.
Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population
Akitoshi Ueno[SUP] 1 [/SUP], Hitoshi Kawasuji[SUP] 1 [/SUP], Yuki Miyajima[SUP] 1 [/SUP], Yasutaka Fukui[SUP] 1 [/SUP], Ippei Sakamaki[SUP] 1 [/SUP], Mayuko Saito[SUP] 2 [/SUP], Seiji Yamashiro[SUP] 2 [/SUP], Yoshitomo Morinaga[SUP] 3 [/SUP], Kazunori Oishi[SUP] 4 [/SUP], Yoshihiro Yamamoto[SUP] 5 [/SUP]
Affiliations
Abstract
Introduction: The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
Methods: This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
Results: A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75-35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
Conclusion: This study demonstrated that viral clearance tends to be sustained in the older adults.
Keywords: COVID-19; Viral clearance; qRT-PCR.
. 2021 Mar 11;S1341-321X(21)00081-7.
doi: 10.1016/j.jiac.2021.03.007. Online ahead of print.
Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population
Akitoshi Ueno[SUP] 1 [/SUP], Hitoshi Kawasuji[SUP] 1 [/SUP], Yuki Miyajima[SUP] 1 [/SUP], Yasutaka Fukui[SUP] 1 [/SUP], Ippei Sakamaki[SUP] 1 [/SUP], Mayuko Saito[SUP] 2 [/SUP], Seiji Yamashiro[SUP] 2 [/SUP], Yoshitomo Morinaga[SUP] 3 [/SUP], Kazunori Oishi[SUP] 4 [/SUP], Yoshihiro Yamamoto[SUP] 5 [/SUP]
Affiliations
- PMID: 33781692
- DOI: 10.1016/j.jiac.2021.03.007
Abstract
Introduction: The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
Methods: This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
Results: A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75-35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
Conclusion: This study demonstrated that viral clearance tends to be sustained in the older adults.
Keywords: COVID-19; Viral clearance; qRT-PCR.