tetano
Editor, Senior Moderator
J Infect Dis
. 2023 May 24;jiad178.
doi: 10.1093/infdis/jiad178. Online ahead of print. Changes in anti-SARS-CoV-2 antibody titers of pooled plasma derived from donors in Japan: a potential tool for mass-immunity evaluation
Mikihiro Yunoki[SUP] 1 2 [/SUP], Ritsuko Kubota-Koketsu[SUP] 2 [/SUP], Teruaki Imada[SUP] 1 [/SUP], Kazuhiro Furuyama[SUP] 3 [/SUP], Takahiro Sasaki[SUP] 3 [/SUP], Shinichi Ohashi[SUP] 3 [/SUP], Tatsuo Shioda[SUP] 2 [/SUP]
Affiliations
The anti-spike (S), anti-nucleocapsid (N), and neutralizing activities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of pooled plasma derived from donors in Japan from January 2021 to April 2022 were evaluated. Anti-S titers and neutralizing activities showed a wave-like trend affected by daily vaccinations and/or the number of reported cases of SARS-CoV-2 infections, whereas anti-N titers remained at negative levels. These results suggest that anti-S and neutralizing titers would fluctuate in pooled plasma in future. Pooled plasma may be potentially used for mass-immunity evaluation, and titer estimation in intravenous immunoglobulin, a derivative of pooled plasma.
Keywords: COVID-19; IVIG; SARS-CoV-2; anti-N; anti-S; epidemiology; neutralization; vaccination.
. 2023 May 24;jiad178.
doi: 10.1093/infdis/jiad178. Online ahead of print. Changes in anti-SARS-CoV-2 antibody titers of pooled plasma derived from donors in Japan: a potential tool for mass-immunity evaluation
Mikihiro Yunoki[SUP] 1 2 [/SUP], Ritsuko Kubota-Koketsu[SUP] 2 [/SUP], Teruaki Imada[SUP] 1 [/SUP], Kazuhiro Furuyama[SUP] 3 [/SUP], Takahiro Sasaki[SUP] 3 [/SUP], Shinichi Ohashi[SUP] 3 [/SUP], Tatsuo Shioda[SUP] 2 [/SUP]
Affiliations
- PMID: 37224513
- DOI: 10.1093/infdis/jiad178
The anti-spike (S), anti-nucleocapsid (N), and neutralizing activities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of pooled plasma derived from donors in Japan from January 2021 to April 2022 were evaluated. Anti-S titers and neutralizing activities showed a wave-like trend affected by daily vaccinations and/or the number of reported cases of SARS-CoV-2 infections, whereas anti-N titers remained at negative levels. These results suggest that anti-S and neutralizing titers would fluctuate in pooled plasma in future. Pooled plasma may be potentially used for mass-immunity evaluation, and titer estimation in intravenous immunoglobulin, a derivative of pooled plasma.
Keywords: COVID-19; IVIG; SARS-CoV-2; anti-N; anti-S; epidemiology; neutralization; vaccination.