tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Jun 30;jiaa380.
doi: 10.1093/infdis/jiaa380. Online ahead of print.
Clinical Outcomes and Immunologic Characteristics of Covid-19 in People With HIV
Hsi-En Ho[SUP] 1 [/SUP], Michael J Peluso[SUP] 2 [/SUP], Colton Margus[SUP] 1 [/SUP], Joao Pedro Matias Lopes[SUP] 1 [/SUP], Chen He[SUP] 1 [/SUP], Michael M Gaisa[SUP] 1 [/SUP], Georgina Osorio[SUP] 1 [/SUP], Judith A Aberg[SUP] 1 [/SUP], Michael P Mullen[SUP] 1 [/SUP]
AffiliationsExpand
Abstract
We performed a retrospective study of Covid-19 in people with HIV (PWH). PWH with Covid-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin-6, interleukin-8, and TNF-alpha were commonly elevated. In all, 19/72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of Covid-19 despite ART and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.
Keywords: Covid-19; HIV; SARS-CoV-2; coronavirus; inflammation; people living with HIV.
. 2020 Jun 30;jiaa380.
doi: 10.1093/infdis/jiaa380. Online ahead of print.
Clinical Outcomes and Immunologic Characteristics of Covid-19 in People With HIV
Hsi-En Ho[SUP] 1 [/SUP], Michael J Peluso[SUP] 2 [/SUP], Colton Margus[SUP] 1 [/SUP], Joao Pedro Matias Lopes[SUP] 1 [/SUP], Chen He[SUP] 1 [/SUP], Michael M Gaisa[SUP] 1 [/SUP], Georgina Osorio[SUP] 1 [/SUP], Judith A Aberg[SUP] 1 [/SUP], Michael P Mullen[SUP] 1 [/SUP]
AffiliationsExpand
- PMID: 32601704
- DOI: 10.1093/infdis/jiaa380
Abstract
We performed a retrospective study of Covid-19 in people with HIV (PWH). PWH with Covid-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin-6, interleukin-8, and TNF-alpha were commonly elevated. In all, 19/72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of Covid-19 despite ART and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.
Keywords: Covid-19; HIV; SARS-CoV-2; coronavirus; inflammation; people living with HIV.