tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Apr 27;jiac152.
doi: 10.1093/infdis/jiac152. Online ahead of print.
Immunological correlates of prevention of the onset of seasonal H3N2 influenza
Moe Okuda[SUP] 1 [/SUP], Yuko Sakai-Tagawa[SUP] 1 2 [/SUP], Michiko Koga[SUP] 3 [/SUP], Tomohiko Koibuchi[SUP] 4 [/SUP], Tadashi Kikuchi[SUP] 4 [/SUP], Eisuke Adachi[SUP] 4 [/SUP], Lay Ahyoung Lim[SUP] 4 [/SUP], Shinya Yamamoto[SUP] 1 3 [/SUP], Hiroshi Yotsuyanagi[SUP] 3 4 [/SUP], Kyota Negishi[SUP] 5 [/SUP], Daisuke Jubishi[SUP] 5 6 [/SUP], Seiya Yamayoshi[SUP] 1 2 7 [/SUP], Yoshihiro Kawaoka[SUP] 1 2 7 8 [/SUP]
Affiliations
Abstract
Upon influenza virus infection or vaccination, immune responses occur including the production of antibodies with various functions that contributes to protection from seasonal influenza virus infection. Here, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinical individuals and 16 patients who were infected with seasonal H3N2 virus. For antibody titers prior to the influenza virus exposure, we found that the neutralizing titers and ELISA titers against HA and NA proteins for the subclinical individuals were significantly higher than those for the patients, whereas the neuraminidase-inhibition (NI) titers and antibody-dependent cellular cytotoxicity (ADCC) activities did not significantly differ between subclinical individuals and patients. These results suggest that neutralizing titers and ELISA titers against HA and NA serve as correlates of symptomatic influenza infection.
Keywords: H3N2; Influenza A virus; antibody functions that inhibit influenza infection; correlates of protection; subclinical infection.
. 2022 Apr 27;jiac152.
doi: 10.1093/infdis/jiac152. Online ahead of print.
Immunological correlates of prevention of the onset of seasonal H3N2 influenza
Moe Okuda[SUP] 1 [/SUP], Yuko Sakai-Tagawa[SUP] 1 2 [/SUP], Michiko Koga[SUP] 3 [/SUP], Tomohiko Koibuchi[SUP] 4 [/SUP], Tadashi Kikuchi[SUP] 4 [/SUP], Eisuke Adachi[SUP] 4 [/SUP], Lay Ahyoung Lim[SUP] 4 [/SUP], Shinya Yamamoto[SUP] 1 3 [/SUP], Hiroshi Yotsuyanagi[SUP] 3 4 [/SUP], Kyota Negishi[SUP] 5 [/SUP], Daisuke Jubishi[SUP] 5 6 [/SUP], Seiya Yamayoshi[SUP] 1 2 7 [/SUP], Yoshihiro Kawaoka[SUP] 1 2 7 8 [/SUP]
Affiliations
- PMID: 35478039
- DOI: 10.1093/infdis/jiac152
Abstract
Upon influenza virus infection or vaccination, immune responses occur including the production of antibodies with various functions that contributes to protection from seasonal influenza virus infection. Here, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinical individuals and 16 patients who were infected with seasonal H3N2 virus. For antibody titers prior to the influenza virus exposure, we found that the neutralizing titers and ELISA titers against HA and NA proteins for the subclinical individuals were significantly higher than those for the patients, whereas the neuraminidase-inhibition (NI) titers and antibody-dependent cellular cytotoxicity (ADCC) activities did not significantly differ between subclinical individuals and patients. These results suggest that neutralizing titers and ELISA titers against HA and NA serve as correlates of symptomatic influenza infection.
Keywords: H3N2; Influenza A virus; antibody functions that inhibit influenza infection; correlates of protection; subclinical infection.