tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Oct 22;jiaa665.
doi: 10.1093/infdis/jiaa665. Online ahead of print.
Impact of Immune Priming, Vaccination and Infection on Influenza A(H3N2) Antibody Landscapes in Children
Michael Hinojosa[SUP] 1 2 [/SUP], Samuel S Shepard[SUP] 1 [/SUP], Jessie R Chung[SUP] 1 [/SUP], Jennifer P King[SUP] 3 [/SUP], Huong Q McLean[SUP] 3 [/SUP], Brendan Flannery[SUP] 1 [/SUP], Edward A Belongia[SUP] 3 [/SUP], Min Z Levine[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Pre-existing antibodies to influenza, shaped by early infection and subsequent exposures, may impact responses to influenza vaccination.
Methods: We enrolled 72 children (7-17 years) in 2015-16, all received inactivated influenza vaccines. Forty-one were also vaccinated in 2014-15 with 12 became infected with A(H3N2) in 2014-15. Thirty-one children did not have documented influenza exposures in the prior 5 seasons. Sera were collected pre- and post-vaccination in both seasons. We constructed antibody landscapes using hemagglutination inhibition antibody titers against 16 A(H3N2) viruses representative of major antigenic clusters that circulated between 1968 and 2015.
Results: The breadth of the antibody landscapes increased with age. Vaccine-induced antibody responses correlated with boosting of titers to previously encountered antigens. Post-vaccination titers were highest against vaccine antigens rather than the historic A(H3N2) viruses previously encountered. Pre-vaccination titers to the vaccine were the strongest predictors of post-vaccination titers. Responses to vaccine antigens did not differ by likely priming virus. Influenza A(H3N2) infected children in 2014-15 had narrower antibody landscapes than those uninfected, but prior season infection status had little effect on antibody landscapes following 2015-16 vaccination.
Conclusions: A(H3N2) antibody landscapes in children were largely determined by age-related immune priming, rather than recent vaccination or infection.
Keywords: antibody landscape; birth cohorts; immune priming; infection; influenza vaccination
. 2020 Oct 22;jiaa665.
doi: 10.1093/infdis/jiaa665. Online ahead of print.
Impact of Immune Priming, Vaccination and Infection on Influenza A(H3N2) Antibody Landscapes in Children
Michael Hinojosa[SUP] 1 2 [/SUP], Samuel S Shepard[SUP] 1 [/SUP], Jessie R Chung[SUP] 1 [/SUP], Jennifer P King[SUP] 3 [/SUP], Huong Q McLean[SUP] 3 [/SUP], Brendan Flannery[SUP] 1 [/SUP], Edward A Belongia[SUP] 3 [/SUP], Min Z Levine[SUP] 1 [/SUP]
Affiliations
- PMID: 33090202
- DOI: 10.1093/infdis/jiaa665
Abstract
Background: Pre-existing antibodies to influenza, shaped by early infection and subsequent exposures, may impact responses to influenza vaccination.
Methods: We enrolled 72 children (7-17 years) in 2015-16, all received inactivated influenza vaccines. Forty-one were also vaccinated in 2014-15 with 12 became infected with A(H3N2) in 2014-15. Thirty-one children did not have documented influenza exposures in the prior 5 seasons. Sera were collected pre- and post-vaccination in both seasons. We constructed antibody landscapes using hemagglutination inhibition antibody titers against 16 A(H3N2) viruses representative of major antigenic clusters that circulated between 1968 and 2015.
Results: The breadth of the antibody landscapes increased with age. Vaccine-induced antibody responses correlated with boosting of titers to previously encountered antigens. Post-vaccination titers were highest against vaccine antigens rather than the historic A(H3N2) viruses previously encountered. Pre-vaccination titers to the vaccine were the strongest predictors of post-vaccination titers. Responses to vaccine antigens did not differ by likely priming virus. Influenza A(H3N2) infected children in 2014-15 had narrower antibody landscapes than those uninfected, but prior season infection status had little effect on antibody landscapes following 2015-16 vaccination.
Conclusions: A(H3N2) antibody landscapes in children were largely determined by age-related immune priming, rather than recent vaccination or infection.
Keywords: antibody landscape; birth cohorts; immune priming; infection; influenza vaccination