tetano
Editor, Senior Moderator
J Infect Dis
. 2024 Jul 16:jiae361.
doi: 10.1093/infdis/jiae361. Online ahead of print. Intranasal M2SR (M2-deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults
Lindsay Hill-Batorski[SUP] 1 [/SUP], Joshua A Weiner[SUP] 2 [/SUP], Margaret E Ackerman[SUP] 2 [/SUP], Yasuko Hatta[SUP] 1 [/SUP], Daniel F Hoft[SUP] 3 [/SUP], Renee Herber[SUP] 1 [/SUP], Michael J Moser[SUP] 1 [/SUP], Pamuk Bilsel[SUP] 1 [/SUP]
Affiliations
Intranasal M2SR (M2-deficient Single Replication influenza virus) vaccine induces robust immune responses in animal models and human subjects. A high-throughput multiplexed platform was used to analyze hemagglutinin-specific mucosal antibody responses in adults after a single dose of H3N2 M2SR. Nasal swab specimens were analyzed for total and hemagglutinin-specific IgA. Significant, dose-dependent increases in mucosal antibody responses to vaccine-matched and drifted H3N2 hemagglutinin were observed in M2SR vaccinated subjects regardless of baseline serum and mucosal immune status. These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.
Keywords: H3N2; IgA; Influenza; clinical trial; drift; intranasal; mucosal; vaccine.
. 2024 Jul 16:jiae361.
doi: 10.1093/infdis/jiae361. Online ahead of print. Intranasal M2SR (M2-deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults
Lindsay Hill-Batorski[SUP] 1 [/SUP], Joshua A Weiner[SUP] 2 [/SUP], Margaret E Ackerman[SUP] 2 [/SUP], Yasuko Hatta[SUP] 1 [/SUP], Daniel F Hoft[SUP] 3 [/SUP], Renee Herber[SUP] 1 [/SUP], Michael J Moser[SUP] 1 [/SUP], Pamuk Bilsel[SUP] 1 [/SUP]
Affiliations
- PMID: 39012796
- DOI: 10.1093/infdis/jiae361
Intranasal M2SR (M2-deficient Single Replication influenza virus) vaccine induces robust immune responses in animal models and human subjects. A high-throughput multiplexed platform was used to analyze hemagglutinin-specific mucosal antibody responses in adults after a single dose of H3N2 M2SR. Nasal swab specimens were analyzed for total and hemagglutinin-specific IgA. Significant, dose-dependent increases in mucosal antibody responses to vaccine-matched and drifted H3N2 hemagglutinin were observed in M2SR vaccinated subjects regardless of baseline serum and mucosal immune status. These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.
Keywords: H3N2; IgA; Influenza; clinical trial; drift; intranasal; mucosal; vaccine.