tetano
Editor, Senior Moderator
J Infect Dis
. 2023 Jan 13;jiad009.
doi: 10.1093/infdis/jiad009. Online ahead of print.
Investigation of impact of childhood immune imprinting on birth year-specific risk of clinical infection during influenza A virus epidemics in Hong Kong
Tim K Tsang[SUP] 1 2 [/SUP], Katelyn M Gostic[SUP] 3 [/SUP], Sijie Chen[SUP] 1 [/SUP], Yifan Wang[SUP] 1 [/SUP], Philip Arevalo[SUP] 3 [/SUP], Eric H Y Lau[SUP] 1 2 [/SUP], Sarah Cobey[SUP] 3 [/SUP], Benjamin J Cowling[SUP] 1 2 [/SUP]
Affiliations
Abstract
Influenza imprinting reduces risks of influenza A virus clinical infection by 40-90% estimated from surveillance data in western countries. We analyzed surveillance data from 2010-2019 in Hong Kong. Based on the best model included HA group-level imprinting, we estimated that individuals imprinted to H1N1 or H2N2 had a 17% (95% CI: 3%, 28%) lower risk of H1N1 clinical infection, and individuals imprinted to H3N2 would have 12% (95% CI: -3%, 26%) lower risk of H3N2 clinical infection. These estimates were weaker than estimated in western countries. Identifying factors affecting imprinting protections is important for control policies and disease modeling.
Keywords: Influenza; imprinting protection; surveillance.
. 2023 Jan 13;jiad009.
doi: 10.1093/infdis/jiad009. Online ahead of print.
Investigation of impact of childhood immune imprinting on birth year-specific risk of clinical infection during influenza A virus epidemics in Hong Kong
Tim K Tsang[SUP] 1 2 [/SUP], Katelyn M Gostic[SUP] 3 [/SUP], Sijie Chen[SUP] 1 [/SUP], Yifan Wang[SUP] 1 [/SUP], Philip Arevalo[SUP] 3 [/SUP], Eric H Y Lau[SUP] 1 2 [/SUP], Sarah Cobey[SUP] 3 [/SUP], Benjamin J Cowling[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36637115
- DOI: 10.1093/infdis/jiad009
Abstract
Influenza imprinting reduces risks of influenza A virus clinical infection by 40-90% estimated from surveillance data in western countries. We analyzed surveillance data from 2010-2019 in Hong Kong. Based on the best model included HA group-level imprinting, we estimated that individuals imprinted to H1N1 or H2N2 had a 17% (95% CI: 3%, 28%) lower risk of H1N1 clinical infection, and individuals imprinted to H3N2 would have 12% (95% CI: -3%, 26%) lower risk of H3N2 clinical infection. These estimates were weaker than estimated in western countries. Identifying factors affecting imprinting protections is important for control policies and disease modeling.
Keywords: Influenza; imprinting protection; surveillance.