tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Nov 29;jiaa744.
doi: 10.1093/infdis/jiaa744. Online ahead of print.
Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 may be predictive of death in Severe Coronavirus Disease 2019 (COVID-19)
Emily R Bowman[SUP] 1 [/SUP], Cheryl M Ainslie Cameron[SUP] 2 [/SUP], Ann Avery[SUP] 3 4 [/SUP], Janelle Gabriel[SUP] 1 [/SUP], Aaren Kettelhut[SUP] 1 [/SUP], Michelle Hecker[SUP] 3 4 [/SUP], Claudia Ute Sontich[SUP] 3 [/SUP], Banumathi Tamilselvan[SUP] 2 [/SUP], Carmen N Nichols[SUP] 5 [/SUP], Brian Richardson[SUP] 2 5 [/SUP], Michael Cartwright[SUP] 5 [/SUP], Nicholas T Funderburg[SUP] 1 [/SUP], Mark J Cameron[SUP] 5 [/SUP]
Affiliations
Abstract
People infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical COVID-19 disease. Levels of monocyte activation (sCD14 and FABP4) and inflammation (TNFR1 and 2) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease that ultimately died.
Keywords: COVID-19; SARS-CoV-2; monocytes; tumor necrosis factor.
. 2020 Nov 29;jiaa744.
doi: 10.1093/infdis/jiaa744. Online ahead of print.
Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 may be predictive of death in Severe Coronavirus Disease 2019 (COVID-19)
Emily R Bowman[SUP] 1 [/SUP], Cheryl M Ainslie Cameron[SUP] 2 [/SUP], Ann Avery[SUP] 3 4 [/SUP], Janelle Gabriel[SUP] 1 [/SUP], Aaren Kettelhut[SUP] 1 [/SUP], Michelle Hecker[SUP] 3 4 [/SUP], Claudia Ute Sontich[SUP] 3 [/SUP], Banumathi Tamilselvan[SUP] 2 [/SUP], Carmen N Nichols[SUP] 5 [/SUP], Brian Richardson[SUP] 2 5 [/SUP], Michael Cartwright[SUP] 5 [/SUP], Nicholas T Funderburg[SUP] 1 [/SUP], Mark J Cameron[SUP] 5 [/SUP]
Affiliations
- PMID: 33249506
- DOI: 10.1093/infdis/jiaa744
Abstract
People infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical COVID-19 disease. Levels of monocyte activation (sCD14 and FABP4) and inflammation (TNFR1 and 2) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease that ultimately died.
Keywords: COVID-19; SARS-CoV-2; monocytes; tumor necrosis factor.