tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Jul 16;jiaa426.
doi: 10.1093/infdis/jiaa426. Online ahead of print.
Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections
Alexandria D Tricoche[SUP] 1 [/SUP], Abram L Wagner[SUP] 1 [/SUP], Angel Balmaseda[SUP] 2 [/SUP], Nery Sanchez[SUP] 3 [/SUP], Mayuri Patel[SUP] 1 [/SUP], Roger Lopez[SUP] 2 3 [/SUP], Amy Schiller[SUP] 1 [/SUP], Sergio Ojeda[SUP] 3 [/SUP], Aaron M Frutos[SUP] 1 [/SUP], Guillermina Kuan[SUP] 3 4 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
Abstract
Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status. Antibody response was assessed using Hemagglutination Inhibition Assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% CI: 1.02, 4.64). Studies relying on serological assays may not generalize to asymptomatic infections.
Keywords: Antibodies; Hemagglutination Inhibition Tests; Infectious Disease Transmission; Influenza A Virus; Signs and Symptoms.
. 2020 Jul 16;jiaa426.
doi: 10.1093/infdis/jiaa426. Online ahead of print.
Symptoms, Infection Duration, and Hemagglutinin Inhibition Antibody Response in Influenza A Infections
Alexandria D Tricoche[SUP] 1 [/SUP], Abram L Wagner[SUP] 1 [/SUP], Angel Balmaseda[SUP] 2 [/SUP], Nery Sanchez[SUP] 3 [/SUP], Mayuri Patel[SUP] 1 [/SUP], Roger Lopez[SUP] 2 3 [/SUP], Amy Schiller[SUP] 1 [/SUP], Sergio Ojeda[SUP] 3 [/SUP], Aaron M Frutos[SUP] 1 [/SUP], Guillermina Kuan[SUP] 3 4 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
- PMID: 32668454
- DOI: 10.1093/infdis/jiaa426
Abstract
Many influenza studies assume that symptomatic and asymptomatic cases have equivalent antibody responses. This study examines the relationship between influenza symptoms and serological response. Influenza-positive index cases and household members in Managua, Nicaragua, during 2012-2017 were categorized by symptom status. Antibody response was assessed using Hemagglutination Inhibition Assays (HAI). Among 510 cases, 74.5% had ≥4-fold increase in HAI antibodies, and 75.3% had febrile illness. In a logistic regression model, febrile cases had 2.17 times higher odds of a ≥4-fold titer rise compared to asymptomatic cases (95% CI: 1.02, 4.64). Studies relying on serological assays may not generalize to asymptomatic infections.
Keywords: Antibodies; Hemagglutination Inhibition Tests; Infectious Disease Transmission; Influenza A Virus; Signs and Symptoms.