tetano
Editor, Senior Moderator
J Infect Public Health
. 2021 Feb 8;14(5):620-627.
doi: 10.1016/j.jiph.2021.02.002. Online ahead of print.
Reactivation of SARS-CoV-2 infection following recovery from COVID-19
Zhihai Chen[SUP] 1 [/SUP], Wen Xie[SUP] 2 [/SUP], Ziruo Ge[SUP] 3 [/SUP], Yajie Wang[SUP] 4 [/SUP], Hong Zhao[SUP] 2 [/SUP], Jingjing Wang[SUP] 2 [/SUP], Yanli Xu[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Meihua Song[SUP] 1 [/SUP], Shuping Cui[SUP] 5 [/SUP], Xiankun Wang[SUP] 3 [/SUP], Calvin Q Pan[SUP] 6 [/SUP]
Affiliations
Abstract
Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors.
Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ?24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed.
Results: Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of <1500/?L (odds ratio [OR]: 0.34, 95% confidence interval [CI]: 0.12-0.94) and two or fewer symptoms (OR: 0.20, 95% CI: 0.07-0.55) during the initial episode.
Conclusion: Risk-stratified surveillance should be conducted among patients who have recovered from COVID-19.
Keywords: COVID-19 relapse; Coronavirus reactivation; Persistent coronavirus infection; Real-Time reverse transcription-polymerase chain reaction; Recurrent SARS-CoV-2 infection.
. 2021 Feb 8;14(5):620-627.
doi: 10.1016/j.jiph.2021.02.002. Online ahead of print.
Reactivation of SARS-CoV-2 infection following recovery from COVID-19
Zhihai Chen[SUP] 1 [/SUP], Wen Xie[SUP] 2 [/SUP], Ziruo Ge[SUP] 3 [/SUP], Yajie Wang[SUP] 4 [/SUP], Hong Zhao[SUP] 2 [/SUP], Jingjing Wang[SUP] 2 [/SUP], Yanli Xu[SUP] 1 [/SUP], Wei Zhang[SUP] 1 [/SUP], Meihua Song[SUP] 1 [/SUP], Shuping Cui[SUP] 5 [/SUP], Xiankun Wang[SUP] 3 [/SUP], Calvin Q Pan[SUP] 6 [/SUP]
Affiliations
- PMID: 33848891
- DOI: 10.1016/j.jiph.2021.02.002
Abstract
Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors.
Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ?24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed.
Results: Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of <1500/?L (odds ratio [OR]: 0.34, 95% confidence interval [CI]: 0.12-0.94) and two or fewer symptoms (OR: 0.20, 95% CI: 0.07-0.55) during the initial episode.
Conclusion: Risk-stratified surveillance should be conducted among patients who have recovered from COVID-19.
Keywords: COVID-19 relapse; Coronavirus reactivation; Persistent coronavirus infection; Real-Time reverse transcription-polymerase chain reaction; Recurrent SARS-CoV-2 infection.