tetano
Editor, Senior Moderator
J Infect
. 2022 Jul 3;S0163-4453(22)00404-2.
doi: 10.1016/j.jinf.2022.06.030. Online ahead of print.
Spike-mediated ACE2 down-regulation involved in the pathogenesis of SARS-CoV-2 infection
Xiang Gao[SUP] 1 [/SUP], Shengyuan Zhang[SUP] 1 [/SUP], Jizhou Gou[SUP] 2 [/SUP], Yanling Wen[SUP] 1 [/SUP], Lujie Fan[SUP] 3 [/SUP], Jian Zhou[SUP] 1 [/SUP], Guangde Zhou[SUP] 2 [/SUP], Gang Xu[SUP] 1 [/SUP], Zheng Zhang[SUP] 4 [/SUP]
Affiliations
Abstract
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patient. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS.
Keywords: ACE2; Ang II; SARS-CoV-2; Spike.
. 2022 Jul 3;S0163-4453(22)00404-2.
doi: 10.1016/j.jinf.2022.06.030. Online ahead of print.
Spike-mediated ACE2 down-regulation involved in the pathogenesis of SARS-CoV-2 infection
Xiang Gao[SUP] 1 [/SUP], Shengyuan Zhang[SUP] 1 [/SUP], Jizhou Gou[SUP] 2 [/SUP], Yanling Wen[SUP] 1 [/SUP], Lujie Fan[SUP] 3 [/SUP], Jian Zhou[SUP] 1 [/SUP], Guangde Zhou[SUP] 2 [/SUP], Gang Xu[SUP] 1 [/SUP], Zheng Zhang[SUP] 4 [/SUP]
Affiliations
- PMID: 35793758
- DOI: 10.1016/j.jinf.2022.06.030
Abstract
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patient. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS.
Keywords: ACE2; Ang II; SARS-CoV-2; Spike.