tetano
Editor, Senior Moderator
J Inflamm Res
. 2023 Feb 17;16:665-675.
doi: 10.2147/JIR.S394927. eCollection 2023.
Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis
Alshaymaa M Alhabibi[SUP] 1 [/SUP], Asmaa S Hassan[SUP] 1 [/SUP], Nashwa Mohamed Abd Elbaky[SUP] 1 [/SUP], Hoda Asaad Eid[SUP] 2 [/SUP], Mohie Aldeen Abd Alzaher Khalifa[SUP] 3 [/SUP], Maisa A Wahab[SUP] 4 [/SUP], Azza Ali Althoqapy[SUP] 5 [/SUP], Aml E Abdou[SUP] 5 [/SUP], Doaa Mohammed Zakaria[SUP] 6 [/SUP], Eman Mostafa Nassef[SUP] 6 [/SUP], Sammar Ahmed Kasim[SUP] 6 [/SUP], Ola I Saleh[SUP] 7 [/SUP], Asmaa Abdelghany Elsheikh[SUP] 8 [/SUP], Mahmoud Lotfy[SUP] 9 [/SUP], Alaa Sayed[SUP] 10 [/SUP]
Affiliations
Abstract
Background: Toll-like receptors (TLRs) play an important role in activation of innate and adaptive immune responses.
Aim: We aimed to detect the association between TLR2 rs5743708 G>A and TLR9 rs5743836 C>T variants and COVID-19 disease susceptibility, severity, and thrombosis by using neutrophil extracellular traps (NETs).
Subjects and methods: We included 100 adult COVID-19 patients as well as 100 age- and gender-matched normal controls. Participants were genotyped for TLR2 rs5743708 and TLR9 rs5743836. Citrullinated Histone (H3) was detected as an indicator of NETs.
Results: The mutant (G/A and C/C) genotypes and (A and C) alleles of TLR2 rs5743708 and TLR9 rs5743836, respectively, have been significantly related to a higher risk of COVID-19 infection, representing a significant risk factor for the severity of COVID-19. There was no significant association between the two variants and citrullinated histone (H3).
Conclusion: TLR2 rs5743708 and TLR9 rs5743836 variants have been significantly related to a higher risk and severity of COVID-19 infection but had no effect on thrombus formation.
Keywords: coronavirus disease 2019; high resolution-CT; severity; single-nucleotide polymorphism; susceptibility; toll-like receptor.
. 2023 Feb 17;16:665-675.
doi: 10.2147/JIR.S394927. eCollection 2023.
Impact of Toll-Like Receptor 2 and 9 Gene Polymorphisms on COVID-19: Susceptibility, Severity, and Thrombosis
Alshaymaa M Alhabibi[SUP] 1 [/SUP], Asmaa S Hassan[SUP] 1 [/SUP], Nashwa Mohamed Abd Elbaky[SUP] 1 [/SUP], Hoda Asaad Eid[SUP] 2 [/SUP], Mohie Aldeen Abd Alzaher Khalifa[SUP] 3 [/SUP], Maisa A Wahab[SUP] 4 [/SUP], Azza Ali Althoqapy[SUP] 5 [/SUP], Aml E Abdou[SUP] 5 [/SUP], Doaa Mohammed Zakaria[SUP] 6 [/SUP], Eman Mostafa Nassef[SUP] 6 [/SUP], Sammar Ahmed Kasim[SUP] 6 [/SUP], Ola I Saleh[SUP] 7 [/SUP], Asmaa Abdelghany Elsheikh[SUP] 8 [/SUP], Mahmoud Lotfy[SUP] 9 [/SUP], Alaa Sayed[SUP] 10 [/SUP]
Affiliations
- PMID: 36825132
- PMCID: PMC9942505
- DOI: 10.2147/JIR.S394927
Abstract
Background: Toll-like receptors (TLRs) play an important role in activation of innate and adaptive immune responses.
Aim: We aimed to detect the association between TLR2 rs5743708 G>A and TLR9 rs5743836 C>T variants and COVID-19 disease susceptibility, severity, and thrombosis by using neutrophil extracellular traps (NETs).
Subjects and methods: We included 100 adult COVID-19 patients as well as 100 age- and gender-matched normal controls. Participants were genotyped for TLR2 rs5743708 and TLR9 rs5743836. Citrullinated Histone (H3) was detected as an indicator of NETs.
Results: The mutant (G/A and C/C) genotypes and (A and C) alleles of TLR2 rs5743708 and TLR9 rs5743836, respectively, have been significantly related to a higher risk of COVID-19 infection, representing a significant risk factor for the severity of COVID-19. There was no significant association between the two variants and citrullinated histone (H3).
Conclusion: TLR2 rs5743708 and TLR9 rs5743836 variants have been significantly related to a higher risk and severity of COVID-19 infection but had no effect on thrombus formation.
Keywords: coronavirus disease 2019; high resolution-CT; severity; single-nucleotide polymorphism; susceptibility; toll-like receptor.