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J Int Med Res . Dynamic changes in computed tomography manifestations of 105 patients with novel coronavirus pneumonia in Wuhan, China

tetano

Editor, Senior Moderator
J Int Med Res


. 2020 Nov;48(11):300060520972913.
doi: 10.1177/0300060520972913.
Dynamic changes in computed tomography manifestations of 105 patients with novel coronavirus pneumonia in Wuhan, China


Yueying Pan[SUP] 1 [/SUP], Liming Xia[SUP] 1 [/SUP], Yujin Wang[SUP] 1 [/SUP], Hanxiong Guan[SUP] 1 [/SUP]



Affiliations

Abstract

Objective: To observe the evolution of chest high-resolution computed tomography (HRCT) manifestations in 105 patients with coronavirus disease 2019 (COVID-19).
Methods: One hundred five patients with confirmed COVID-19 were enrolled from 11 January to 9 February 2020. Sequential chest HRCT examinations were performed. Five stages were identified from the onset of initial symptoms: 0-3, 4-7, 8-14, 15-21, and >21 days (Stages A-E, respectively). A semi-quantitative CT scoring system was used to estimate the sum of lung abnormalities in each stage.
Results: In total, 393 CT scans were collected. The patients underwent 3.8 ? 1.5 CT examinations. Multiple lobes were involved in most cases. The proportion of consolidation and the total CT score gradually increased from Stage A to C and gradually decreased from Stage C to E. The total CT score of lung involvement was significantly higher in Stage C than in Stages B and D. The CT score of the lower lobe was significantly higher than the corresponding upper and middle lobes in Stages A to D.
Conclusions: Most patients with COVID-19 had a disease course of >14 days, and the lung lesions in most patients improved after 14 days since initial symptom onset.

Keywords: COVID-19; computed tomography; coronavirus infection; disease course; imaging manifestations; lung disease; pneumonia.
 
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