tetano
Editor, Senior Moderator
J Int Med Res
. 2021 Nov;49(11):3000605211056783.
doi: 10.1177/03000605211056783.
Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
Se Il Kim[SUP] 1 [/SUP], Hung Youl Seok[SUP] 2 [/SUP], Jaehyuck Yi[SUP] 3 [/SUP], Jang Hyuk Cho[SUP] 1 [/SUP]
Affiliations
Abstract
The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.
Keywords: Coronavirus disease 2019; case report; complication; lumbosacral plexus; paralysis; vaccination.
. 2021 Nov;49(11):3000605211056783.
doi: 10.1177/03000605211056783.
Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
Se Il Kim[SUP] 1 [/SUP], Hung Youl Seok[SUP] 2 [/SUP], Jaehyuck Yi[SUP] 3 [/SUP], Jang Hyuk Cho[SUP] 1 [/SUP]
Affiliations
- PMID: 34816739
- DOI: 10.1177/03000605211056783
Abstract
The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.
Keywords: Coronavirus disease 2019; case report; complication; lumbosacral plexus; paralysis; vaccination.