tetano
Editor, Senior Moderator
J Int Med Res
. 2020 Aug;48(8):300060520949039.
doi: 10.1177/0300060520949039.
Retrospective analysis of clinical characteristics of 405 patients with COVID-19
Ting Zhan[SUP] 1 [/SUP], Meng Liu[SUP] 1 [/SUP], Yalin Tang[SUP] 1 2 [/SUP], Zheng Han[SUP] 1 [/SUP], Xueting Cheng[SUP] 3 [/SUP], Junsheng Deng[SUP] 3 [/SUP], Xiaoli Chen[SUP] 1 [/SUP], Xia Tian[SUP] 1 [/SUP], Xiaodong Huang[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.
Results: The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.
Conclusion: SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.
Keywords: COVID-19; SARS-CoV-2; Wuhan; clinical characteristics; fever; gastrointestinal symptoms.
. 2020 Aug;48(8):300060520949039.
doi: 10.1177/0300060520949039.
Retrospective analysis of clinical characteristics of 405 patients with COVID-19
Ting Zhan[SUP] 1 [/SUP], Meng Liu[SUP] 1 [/SUP], Yalin Tang[SUP] 1 2 [/SUP], Zheng Han[SUP] 1 [/SUP], Xueting Cheng[SUP] 3 [/SUP], Junsheng Deng[SUP] 3 [/SUP], Xiaoli Chen[SUP] 1 [/SUP], Xia Tian[SUP] 1 [/SUP], Xiaodong Huang[SUP] 1 [/SUP]
Affiliations
- PMID: 32865077
- DOI: 10.1177/0300060520949039
Abstract
Objective: This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.
Results: The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.
Conclusion: SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.
Keywords: COVID-19; SARS-CoV-2; Wuhan; clinical characteristics; fever; gastrointestinal symptoms.