tetano
Editor, Senior Moderator
J Int Med Res
. 2021 Dec;49(12):3000605211062783.
doi: 10.1177/03000605211062783.
Secondary bloodstream infection in critically ill patients with COVID-19
Junli Zhang[SUP] 1 [/SUP], Peng Lan[SUP] 2 [/SUP], Jun Yi[SUP] 3 [/SUP], Changming Yang[SUP] 4 [/SUP], Xiaoyan Gong[SUP] 2 [/SUP], Huiqing Ge[SUP] 5 [/SUP], Xiaoling Xu[SUP] 6 [/SUP], Limin Liu[SUP] 7 [/SUP], Jiancang Zhou[SUP] 2 [/SUP], Fangfang Lv[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: Secondary infection, especially bloodstream infection, is an important cause of death in critically ill patients with COVID-19. We aimed to describe secondary bloodstream infection (SBI) in critically ill adults with COVID-19 in the intensive care unit (ICU) and to explore risk factors related to SBI.
Methods: We reviewed all SBI cases among critically ill patients with COVID-19 from 12 February 2020 to 24 March 2020 in the COVID-19 ICU of Jingmen First People's Hospital. We compared risk factors associated with bloodstream infection in this study. All SBIs were confirmed by blood culture.
Results: We identified five cases of SBI among the 32 patients: three with Enterococcus faecium, one mixed septicemia (E. faecium and Candida albicans), and one C. parapsilosis. There were no significant differences between the SBI group and non-SBI group. Significant risk factors for SBI were extracorporeal membrane oxygenation, central venous catheter, indwelling urethral catheter, and nasogastric tube.
Conclusions: Our findings confirmed that the incidence of secondary infection, particularly SBI, and mortality are high among critically ill patients with COVID-19. We showed that long-term hospitalization and invasive procedures such as tracheotomy, central venous catheter, indwelling urethral catheter, and nasogastric tube are risk factors for SBI and other complications.
Keywords: Coronavirus disease 2019; critical illness; extracorporeal membrane oxygenation; risk factor; secondary bloodstream infection; secondary pneumonia.
. 2021 Dec;49(12):3000605211062783.
doi: 10.1177/03000605211062783.
Secondary bloodstream infection in critically ill patients with COVID-19
Junli Zhang[SUP] 1 [/SUP], Peng Lan[SUP] 2 [/SUP], Jun Yi[SUP] 3 [/SUP], Changming Yang[SUP] 4 [/SUP], Xiaoyan Gong[SUP] 2 [/SUP], Huiqing Ge[SUP] 5 [/SUP], Xiaoling Xu[SUP] 6 [/SUP], Limin Liu[SUP] 7 [/SUP], Jiancang Zhou[SUP] 2 [/SUP], Fangfang Lv[SUP] 1 [/SUP]
Affiliations
- PMID: 34898307
- DOI: 10.1177/03000605211062783
Abstract
Objective: Secondary infection, especially bloodstream infection, is an important cause of death in critically ill patients with COVID-19. We aimed to describe secondary bloodstream infection (SBI) in critically ill adults with COVID-19 in the intensive care unit (ICU) and to explore risk factors related to SBI.
Methods: We reviewed all SBI cases among critically ill patients with COVID-19 from 12 February 2020 to 24 March 2020 in the COVID-19 ICU of Jingmen First People's Hospital. We compared risk factors associated with bloodstream infection in this study. All SBIs were confirmed by blood culture.
Results: We identified five cases of SBI among the 32 patients: three with Enterococcus faecium, one mixed septicemia (E. faecium and Candida albicans), and one C. parapsilosis. There were no significant differences between the SBI group and non-SBI group. Significant risk factors for SBI were extracorporeal membrane oxygenation, central venous catheter, indwelling urethral catheter, and nasogastric tube.
Conclusions: Our findings confirmed that the incidence of secondary infection, particularly SBI, and mortality are high among critically ill patients with COVID-19. We showed that long-term hospitalization and invasive procedures such as tracheotomy, central venous catheter, indwelling urethral catheter, and nasogastric tube are risk factors for SBI and other complications.
Keywords: Coronavirus disease 2019; critical illness; extracorporeal membrane oxygenation; risk factor; secondary bloodstream infection; secondary pneumonia.