tetano
Editor, Senior Moderator
J Integr Neurosci
. 2024 Apr 1;23(4):68.
doi: 10.31083/j.jin2304068. Causal Associations between Posttraumatic Stress Disorder and COVID-19
Ancha Baranova[SUP] 1 2 [/SUP], Li Fu[SUP] 3 [/SUP], Yuqing Song[SUP] 4 5 [/SUP], Hongbao Cao[SUP] 1 [/SUP], Fuquan Zhang[SUP] 3 6 [/SUP]
Affiliations
Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19.
Methods: We investigated potential causal associations between PTSD and two COVID-19 conditions (COVID-19 hospitalization and SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including PTSD (N = 174,659), SARS-CoV-2 infection (N = 2,597,856), and COVID-19 hospitalization (N = 2,095,324). We performed a literature-based analysis to uncover molecular pathways connecting PTSD and COVID-19.
Results: We found that PTSD exerts a causal effect on SARS-CoV-2 infection (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00-1.21, p = 0.048) and hospitalized COVID-19 (OR: 1.34, 95% CI: 1.07-1.67, p = 0.001). However, both SARS-CoV-2 infection and hospitalized COVID-19 were not associated with the risk of PTSD. Pathway analysis revealed that several immunity-related genes may link PTSD to COVID-19.
Conclusions: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.
Keywords: COVID-19; Mendelian randomization; posttraumatic stress disorder.
. 2024 Apr 1;23(4):68.
doi: 10.31083/j.jin2304068. Causal Associations between Posttraumatic Stress Disorder and COVID-19
Ancha Baranova[SUP] 1 2 [/SUP], Li Fu[SUP] 3 [/SUP], Yuqing Song[SUP] 4 5 [/SUP], Hongbao Cao[SUP] 1 [/SUP], Fuquan Zhang[SUP] 3 6 [/SUP]
Affiliations
- PMID: 38682223
- DOI: 10.31083/j.jin2304068
Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19.
Methods: We investigated potential causal associations between PTSD and two COVID-19 conditions (COVID-19 hospitalization and SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including PTSD (N = 174,659), SARS-CoV-2 infection (N = 2,597,856), and COVID-19 hospitalization (N = 2,095,324). We performed a literature-based analysis to uncover molecular pathways connecting PTSD and COVID-19.
Results: We found that PTSD exerts a causal effect on SARS-CoV-2 infection (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00-1.21, p = 0.048) and hospitalized COVID-19 (OR: 1.34, 95% CI: 1.07-1.67, p = 0.001). However, both SARS-CoV-2 infection and hospitalized COVID-19 were not associated with the risk of PTSD. Pathway analysis revealed that several immunity-related genes may link PTSD to COVID-19.
Conclusions: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.
Keywords: COVID-19; Mendelian randomization; posttraumatic stress disorder.