tetano
Editor, Senior Moderator
J Intensive Care
. 2023 Jul 5;11(1):30.
doi: 10.1186/s40560-023-00679-y. Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
Francesco Bellanti[SUP] 1 [/SUP], Sławomir Kasperczyk[SUP] 2 [/SUP], Aleksandra Kasperczyk[SUP] 2 [/SUP], Michał Dobrakowski[SUP] 2 [/SUP], Gabriella Pacilli[SUP] 3 [/SUP], Giuseppina Vurchio[SUP] 3 [/SUP], Alessandro Maddalena[SUP] 3 [/SUP], Stefano Quiete[SUP] 3 [/SUP], Aurelio Lo Buglio[SUP] 3 [/SUP], Cristiano Capurso[SUP] 3 [/SUP], Gaetano Serviddio[SUP] 3 [/SUP], Gianluigi Vendemiale[SUP] 3 [/SUP]
Affiliations
Background: Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease.
Methods: Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19). Circulating markers of redox balance were measured in serum and erythrocytes, and related to markers of inflammation and coagulability.
Results: No differences in serum markers of oxidative damage were found between both groups, but a reduction in total antioxidant status and serum ceruloplasmin level was observed in COVID-19 rather than No COVID-19 patients. Redox balance alterations were described in erythrocytes from COVID-19 with respect to No COVID-19 group, characterized by increased lipofuscin and malondialdehyde concentration, and reduced glutathione S-transferase and glutathione reductase activity. These markers were associated with circulating indexes of respiratory disease severity (Horowitz index and alveolar-to-arterial oxygen gradient), inflammation (interleukin-6 and interleukin-10), and hypercoagulability (D-dimer) in COVID-19 patients with ARDS.
Conclusions: ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19.
Keywords: Acute respiratory distress syndrome; COVID-19; Erythrocyte oxidative stress; Hypercoagulability; Inflammation; Redox-dependent markers; Respiratory failure.
. 2023 Jul 5;11(1):30.
doi: 10.1186/s40560-023-00679-y. Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
Francesco Bellanti[SUP] 1 [/SUP], Sławomir Kasperczyk[SUP] 2 [/SUP], Aleksandra Kasperczyk[SUP] 2 [/SUP], Michał Dobrakowski[SUP] 2 [/SUP], Gabriella Pacilli[SUP] 3 [/SUP], Giuseppina Vurchio[SUP] 3 [/SUP], Alessandro Maddalena[SUP] 3 [/SUP], Stefano Quiete[SUP] 3 [/SUP], Aurelio Lo Buglio[SUP] 3 [/SUP], Cristiano Capurso[SUP] 3 [/SUP], Gaetano Serviddio[SUP] 3 [/SUP], Gianluigi Vendemiale[SUP] 3 [/SUP]
Affiliations
- PMID: 37408073
- DOI: 10.1186/s40560-023-00679-y
Background: Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease.
Methods: Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19). Circulating markers of redox balance were measured in serum and erythrocytes, and related to markers of inflammation and coagulability.
Results: No differences in serum markers of oxidative damage were found between both groups, but a reduction in total antioxidant status and serum ceruloplasmin level was observed in COVID-19 rather than No COVID-19 patients. Redox balance alterations were described in erythrocytes from COVID-19 with respect to No COVID-19 group, characterized by increased lipofuscin and malondialdehyde concentration, and reduced glutathione S-transferase and glutathione reductase activity. These markers were associated with circulating indexes of respiratory disease severity (Horowitz index and alveolar-to-arterial oxygen gradient), inflammation (interleukin-6 and interleukin-10), and hypercoagulability (D-dimer) in COVID-19 patients with ARDS.
Conclusions: ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19.
Keywords: Acute respiratory distress syndrome; COVID-19; Erythrocyte oxidative stress; Hypercoagulability; Inflammation; Redox-dependent markers; Respiratory failure.