J Intensive Care . Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

[tetano]

J Intensive Care


. 2021 Dec 20;9(1):76.
doi: 10.1186/s40560-021-00591-3.
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19


Yumi Mitsuyama[SUP] 1 [/SUP], Kazuma Yamakawa[SUP] 2 [/SUP], Katsuhide Kayano[SUP] 3 [/SUP], Miho Maruyama[SUP] 1 [/SUP], Takeshi Wada[SUP] 4 [/SUP], Satoshi Fujimi[SUP] 1 [/SUP]



Affiliations

• PMID: 34930468
• DOI: 10.1186/s40560-021-00591-3

Abstract

We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry. The patients with prolonged hospitalization did not show recovery of B lymphocyte counts and CD4-positive T lymphocyte counts but did show abundant CD8-positive T lymphocytes. CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B were more abundant in post-recovery patients. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.

Keywords: COVID-19; Cytotoxic T lymphocytes; Granzyme B; Post-recovery; Single-cell mass cytometry; T-bet.