tetano
Editor, Senior Moderator
J Intern Med
. 2022 Jul 4.
doi: 10.1111/joim.13542. Online ahead of print.
Early SARS-CoV-2 associated acute transverse myelitis: A case for neurotropism?
Irene F Lu[SUP] 1 [/SUP], Jack S Cornish[SUP] 1 [/SUP], Aadith Ashok[SUP] 1 [/SUP], Siew Kar Chen[SUP] 1 [/SUP], Eugene Athan[SUP] 1 2 [/SUP], Andrew Hughes[SUP] 1 [/SUP]
Affiliations
Abstract
There are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of Severe-Acute-Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology three days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and Remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2 associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of Remdesivir in the therapeutic regimen. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-COV-2; myelitis; neurotropism.
. 2022 Jul 4.
doi: 10.1111/joim.13542. Online ahead of print.
Early SARS-CoV-2 associated acute transverse myelitis: A case for neurotropism?
Irene F Lu[SUP] 1 [/SUP], Jack S Cornish[SUP] 1 [/SUP], Aadith Ashok[SUP] 1 [/SUP], Siew Kar Chen[SUP] 1 [/SUP], Eugene Athan[SUP] 1 2 [/SUP], Andrew Hughes[SUP] 1 [/SUP]
Affiliations
- PMID: 35781711
- DOI: 10.1111/joim.13542
Abstract
There are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of Severe-Acute-Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology three days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and Remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2 associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of Remdesivir in the therapeutic regimen. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-COV-2; myelitis; neurotropism.