tetano
Editor, Senior Moderator
J Intern Med
. 2020 Jun 12.
doi: 10.1111/joim.13126. Online ahead of print.
High Frequency of Antiphospholipid Antibodies in Critically-ill COVID-19 Patients: A Link With Hypercoagulability?
Marc Pineton de Chambrun[SUP] 1 2 3 [/SUP], Corinne Frere[SUP] 4 [/SUP], Makoto Miyara[SUP] 5 [/SUP], Zahir Amoura[SUP] 3 [/SUP], Isabelle Martin-Toutain[SUP] 4 [/SUP], Alexis Mathian[SUP] 3 [/SUP], Guillaume Hekimian[SUP] 1 2 [/SUP], Alain Combes[SUP] 1 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and D-dimers levels that have been associated with poor prognosis and high rates of severe pulmonary embolism. A recent report suggested a role for antiphospholipid antibodies (aPLA) in the thrombotic manifestations associated with severe COVID-19. As we also recently noticed unexplained lengthening of activated partial thromboplastin time (aPTT) in some critically ill COVID-19 patients, we explored our patients for aPLA positivity.
Keywords: COVID-19; SARS-CoV-2; antiphospholipid antibody; thrombosis.
. 2020 Jun 12.
doi: 10.1111/joim.13126. Online ahead of print.
High Frequency of Antiphospholipid Antibodies in Critically-ill COVID-19 Patients: A Link With Hypercoagulability?
Marc Pineton de Chambrun[SUP] 1 2 3 [/SUP], Corinne Frere[SUP] 4 [/SUP], Makoto Miyara[SUP] 5 [/SUP], Zahir Amoura[SUP] 3 [/SUP], Isabelle Martin-Toutain[SUP] 4 [/SUP], Alexis Mathian[SUP] 3 [/SUP], Guillaume Hekimian[SUP] 1 2 [/SUP], Alain Combes[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32529774
- DOI: 10.1111/joim.13126
Abstract
Coronavirus disease 2019 (COVID-19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and D-dimers levels that have been associated with poor prognosis and high rates of severe pulmonary embolism. A recent report suggested a role for antiphospholipid antibodies (aPLA) in the thrombotic manifestations associated with severe COVID-19. As we also recently noticed unexplained lengthening of activated partial thromboplastin time (aPTT) in some critically ill COVID-19 patients, we explored our patients for aPLA positivity.
Keywords: COVID-19; SARS-CoV-2; antiphospholipid antibody; thrombosis.