tetano
Editor, Senior Moderator
J Investig Med
. 2024 May 15:10815589241249997.
doi: 10.1177/10815589241249997. Online ahead of print. Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials
Fen Yang[SUP] 1 [/SUP], Guizuo Wang[SUP] 2 [/SUP], Dong Han[SUP] 2 [/SUP]
Affiliations
This systematic review and meta-analysis aimed to determine the efficacy of inhaled corticosteroids (ICS) on mortality in patients with coronavirus disease-2019 (COVID-19). A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on the treatment of COVID-19 with ICS were reviewed. Studies were pooled to risk ratios (RRs), with 95% confidence intervals (CIs). Eleven RCTs (enrolling 5832 participants) met the inclusion criteria. There was no statistically significant difference in COVID-19-related death (RR 0.88, 95% CI 0.38-2.04), all-cause death (RR 1.05, 95% CI 0.49-2.23), and invasive ventilation (RR 1.26, 95% CI 0.60-2.62) between the two groups. ICS was not associated with reduced mortality and invasive ventilation in patients with COVID-19.
Keywords: COVID-19; Mortality; inhaled corticosteroids; meta-analysis.
. 2024 May 15:10815589241249997.
doi: 10.1177/10815589241249997. Online ahead of print. Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials
Fen Yang[SUP] 1 [/SUP], Guizuo Wang[SUP] 2 [/SUP], Dong Han[SUP] 2 [/SUP]
Affiliations
- PMID: 38747526
- DOI: 10.1177/10815589241249997
This systematic review and meta-analysis aimed to determine the efficacy of inhaled corticosteroids (ICS) on mortality in patients with coronavirus disease-2019 (COVID-19). A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on the treatment of COVID-19 with ICS were reviewed. Studies were pooled to risk ratios (RRs), with 95% confidence intervals (CIs). Eleven RCTs (enrolling 5832 participants) met the inclusion criteria. There was no statistically significant difference in COVID-19-related death (RR 0.88, 95% CI 0.38-2.04), all-cause death (RR 1.05, 95% CI 0.49-2.23), and invasive ventilation (RR 1.26, 95% CI 0.60-2.62) between the two groups. ICS was not associated with reduced mortality and invasive ventilation in patients with COVID-19.
Keywords: COVID-19; Mortality; inhaled corticosteroids; meta-analysis.