tetano
Editor, Senior Moderator
J Korean Med Sci
. 2021 Oct 18;36(40):e286.
doi: 10.3346/jkms.2021.36.e286.
Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
Sangjoon Choi[SUP] 1 [/SUP], SangHan Lee[SUP] 2 [/SUP], Jeong-Wook Seo[SUP] 3 [/SUP], Min-Ju Kim[SUP] 3 [/SUP], Yo Han Jeon[SUP] 1 [/SUP], Ji Hyun Park[SUP] 1 [/SUP], Jong Kyu Lee[SUP] 1 [/SUP], Nam Seok Yeo[SUP] 1 [/SUP]
Affiliations
Abstract
We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine.
Keywords: Adverse Event Following Immunization; Coronavirus Disease 19; Myocarditis; Sudden Cardiac Death; Vaccination; mRNA Vaccines.
. 2021 Oct 18;36(40):e286.
doi: 10.3346/jkms.2021.36.e286.
Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
Sangjoon Choi[SUP] 1 [/SUP], SangHan Lee[SUP] 2 [/SUP], Jeong-Wook Seo[SUP] 3 [/SUP], Min-Ju Kim[SUP] 3 [/SUP], Yo Han Jeon[SUP] 1 [/SUP], Ji Hyun Park[SUP] 1 [/SUP], Jong Kyu Lee[SUP] 1 [/SUP], Nam Seok Yeo[SUP] 1 [/SUP]
Affiliations
- PMID: 34664804
- DOI: 10.3346/jkms.2021.36.e286
Abstract
We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine.
Keywords: Adverse Event Following Immunization; Coronavirus Disease 19; Myocarditis; Sudden Cardiac Death; Vaccination; mRNA Vaccines.