tetano
Editor, Senior Moderator
J Matern Fetal Neonatal Med
. 2021 Nov 11;1-4.
doi: 10.1080/14767058.2021.1998894. Online ahead of print.
Clinical symptoms associated with laboratory findings and placental histopathology in full-term, non-infected neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive mothers
Despina D Briana[SUP] 1 [/SUP], Vassiliki Papaevangelou[SUP] 1 [/SUP], Garyfallia Syridou[SUP] 1 [/SUP], Kleopatra Paparizou[SUP] 2 [/SUP], Nikolaos Siafakas[SUP] 3 [/SUP], Anastasia E Konstantinidou[SUP] 2 [/SUP], Ariadne Malamitsi-Puchner[SUP] 1 [/SUP]
Affiliations
Abstract
This study comprehensively examines clinical symptoms, laboratory findings, and placental pathology in 40 cases of singleton full-term SARS-CoV-2 negative neonates. Their mothers, previously healthy, with uncomplicated pregnancies, were infected peripartum and presented COVID-19 symptoms of various severity. Neonates had predominately diarrhea, the yet unreported absent sucking reflex, elevated COVID-19 inflammatory and ischemia/asphyxia markers as serum ferritin, interleukin-6 and cardiac troponin-T, while placentas demonstrated mild vascular and/or inflammatory lesions. We hypothesize that the above placental lesions may be associated with transient perinatal hypoxia resulting in absent sucking reflex, as well as with inflammatory cytokines transfer causing diarrhea.
Keywords: SARS-CoV-2; clinical symptoms; full-term neonates; laboratory findings; placental pathology; sucking reflex.
. 2021 Nov 11;1-4.
doi: 10.1080/14767058.2021.1998894. Online ahead of print.
Clinical symptoms associated with laboratory findings and placental histopathology in full-term, non-infected neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive mothers
Despina D Briana[SUP] 1 [/SUP], Vassiliki Papaevangelou[SUP] 1 [/SUP], Garyfallia Syridou[SUP] 1 [/SUP], Kleopatra Paparizou[SUP] 2 [/SUP], Nikolaos Siafakas[SUP] 3 [/SUP], Anastasia E Konstantinidou[SUP] 2 [/SUP], Ariadne Malamitsi-Puchner[SUP] 1 [/SUP]
Affiliations
- PMID: 34762576
- DOI: 10.1080/14767058.2021.1998894
Abstract
This study comprehensively examines clinical symptoms, laboratory findings, and placental pathology in 40 cases of singleton full-term SARS-CoV-2 negative neonates. Their mothers, previously healthy, with uncomplicated pregnancies, were infected peripartum and presented COVID-19 symptoms of various severity. Neonates had predominately diarrhea, the yet unreported absent sucking reflex, elevated COVID-19 inflammatory and ischemia/asphyxia markers as serum ferritin, interleukin-6 and cardiac troponin-T, while placentas demonstrated mild vascular and/or inflammatory lesions. We hypothesize that the above placental lesions may be associated with transient perinatal hypoxia resulting in absent sucking reflex, as well as with inflammatory cytokines transfer causing diarrhea.
Keywords: SARS-CoV-2; clinical symptoms; full-term neonates; laboratory findings; placental pathology; sucking reflex.