tetano
Editor, Senior Moderator
J Matern Fetal Neonatal Med
. 2022 Mar 13;1-10.
doi: 10.1080/14767058.2022.2047926. Online ahead of print.
Possible vertical transmission of corona virus disease 19 (COVID-19) from infected pregnant mothers to neonates: a multicenter study
Rana Almaghrabi[SUP] 1 [/SUP], Lana A Shaiba[SUP] 2 3 [/SUP], Inas Babic[SUP] 4 [/SUP], Mona Abdelbaky[SUP] 5 [/SUP], Sana Ibrahim Aljuhani[SUP] 6 [/SUP], Magdy Omer[SUP] 7 [/SUP], Hisham Abdelaziz Abdelmaksoud[SUP] 8 [/SUP], Sahar Abdulghani[SUP] 9 10 [/SUP], Adnan Hadid[SUP] 2 3 [/SUP], Maria A Arafah[SUP] 10 [/SUP], Nagoud Mohamed Omar Ali[SUP] 11 [/SUP], Abdulrahman Alamir[SUP] 12 [/SUP], Souad Alateah[SUP] 13 [/SUP], Howaida A Bin Salem[SUP] 13 14 [/SUP], Ahmed Muhammed Alrumaihi[SUP] 14 [/SUP], Mahdyah Bukhari[SUP] 10 [/SUP], Reem Aljubab[SUP] 10 [/SUP], Nora AlSaud[SUP] 2 [/SUP], Abdulkarim F Alhetheel[SUP] 14 [/SUP], Ali M Somily[SUP] 14 [/SUP], Ahmed M Albarrag[SUP] 14 [/SUP], Hadil Mohammad Alahdal[SUP] 15 [/SUP], Hana Sonbol[SUP] 16 [/SUP], Abdulrahman Alnemri[SUP] 2 3 [/SUP], Fahad Alzamil[SUP] 2 15 [/SUP]
Affiliations
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious with various possible routes of transmission, resulting in high mortality globally. Controversy exists regarding the vertical transmission of the SARS-CoV-2 infection to fetuses of COVID-19-infected women. The aim of this study was to investigate the possibility of the vertical transmission of SARS-CoV-2 from COVID-19-infected mothers to their neonates.
Materials and methods: We prospectively collected demographical and clinical characteristics of 31 COVID-19 positive pregnant women and their neonates. All mothers and neonates were tested for SARS-CoV-2 infection using the real-time polymerase chain reaction on nasopharyngeal swabs and breast milk samples. Antenatal and placental abnormalities were ultrasonically and histopathologically examined. In cord blood samples, the immunoglobins (Ig) M and IgG were estimated qualitatively.
Results: The women's mean age and gestational age were 31 years and 38 weeks, respectively, with 58% undergoing an elective cesarean section. Gestational diabetes was reported in 29% of cases, 64.5% of women were medically free and only 16.12% were symptomatic. A normal antenatal ultrasound was observed in 77.42% of cases. Nine cord blood samples were positive for IgG. Villous infarction (24%), villous agglutination, and chorangiosis (51%), accelerated villous maturation (21%) and reduced and hypercoiling were reported for 6.97% of the umbilical cords. Three newborns had possible vertical transmission of SARS-CoV-2 infection, of which, two were preterm and IUFD. The third neonate was born full-term, admitted to NICU and later discharged in good health.
Conclusion: Our findings support the possibility of the direct vertical transmission of the SARS-CoV-2 infection to neonates from infected mothers. Further studies with a larger sample size are required to validate the current findings.
Keywords: IUFD; RT-PCR; SARSCoV-2; immunoglobins; neonates; vertical transmission.
. 2022 Mar 13;1-10.
doi: 10.1080/14767058.2022.2047926. Online ahead of print.
Possible vertical transmission of corona virus disease 19 (COVID-19) from infected pregnant mothers to neonates: a multicenter study
Rana Almaghrabi[SUP] 1 [/SUP], Lana A Shaiba[SUP] 2 3 [/SUP], Inas Babic[SUP] 4 [/SUP], Mona Abdelbaky[SUP] 5 [/SUP], Sana Ibrahim Aljuhani[SUP] 6 [/SUP], Magdy Omer[SUP] 7 [/SUP], Hisham Abdelaziz Abdelmaksoud[SUP] 8 [/SUP], Sahar Abdulghani[SUP] 9 10 [/SUP], Adnan Hadid[SUP] 2 3 [/SUP], Maria A Arafah[SUP] 10 [/SUP], Nagoud Mohamed Omar Ali[SUP] 11 [/SUP], Abdulrahman Alamir[SUP] 12 [/SUP], Souad Alateah[SUP] 13 [/SUP], Howaida A Bin Salem[SUP] 13 14 [/SUP], Ahmed Muhammed Alrumaihi[SUP] 14 [/SUP], Mahdyah Bukhari[SUP] 10 [/SUP], Reem Aljubab[SUP] 10 [/SUP], Nora AlSaud[SUP] 2 [/SUP], Abdulkarim F Alhetheel[SUP] 14 [/SUP], Ali M Somily[SUP] 14 [/SUP], Ahmed M Albarrag[SUP] 14 [/SUP], Hadil Mohammad Alahdal[SUP] 15 [/SUP], Hana Sonbol[SUP] 16 [/SUP], Abdulrahman Alnemri[SUP] 2 3 [/SUP], Fahad Alzamil[SUP] 2 15 [/SUP]
Affiliations
- PMID: 35282749
- DOI: 10.1080/14767058.2022.2047926
Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious with various possible routes of transmission, resulting in high mortality globally. Controversy exists regarding the vertical transmission of the SARS-CoV-2 infection to fetuses of COVID-19-infected women. The aim of this study was to investigate the possibility of the vertical transmission of SARS-CoV-2 from COVID-19-infected mothers to their neonates.
Materials and methods: We prospectively collected demographical and clinical characteristics of 31 COVID-19 positive pregnant women and their neonates. All mothers and neonates were tested for SARS-CoV-2 infection using the real-time polymerase chain reaction on nasopharyngeal swabs and breast milk samples. Antenatal and placental abnormalities were ultrasonically and histopathologically examined. In cord blood samples, the immunoglobins (Ig) M and IgG were estimated qualitatively.
Results: The women's mean age and gestational age were 31 years and 38 weeks, respectively, with 58% undergoing an elective cesarean section. Gestational diabetes was reported in 29% of cases, 64.5% of women were medically free and only 16.12% were symptomatic. A normal antenatal ultrasound was observed in 77.42% of cases. Nine cord blood samples were positive for IgG. Villous infarction (24%), villous agglutination, and chorangiosis (51%), accelerated villous maturation (21%) and reduced and hypercoiling were reported for 6.97% of the umbilical cords. Three newborns had possible vertical transmission of SARS-CoV-2 infection, of which, two were preterm and IUFD. The third neonate was born full-term, admitted to NICU and later discharged in good health.
Conclusion: Our findings support the possibility of the direct vertical transmission of the SARS-CoV-2 infection to neonates from infected mothers. Further studies with a larger sample size are required to validate the current findings.
Keywords: IUFD; RT-PCR; SARSCoV-2; immunoglobins; neonates; vertical transmission.